Zeng Jing, Zhang Xianghong, Lin Zhengjun, Zhang Yu, Yang Jing, Dou Pengcheng, Liu Tang
Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Department of Orthopedics, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Exp Hematol Oncol. 2024 Mar 12;13(1):31. doi: 10.1186/s40164-024-00498-3.
Sarcoma is a malignant tumor that originates from mesenchymal tissue. The common treatment for sarcoma is surgery supplemented with radiotherapy and chemotherapy. However, patients have a 5-year survival rate of only approximately 60%, and sarcoma cells are highly resistant to chemotherapy. Ferroptosis is an iron-dependent nonapoptotic type of regulated programmed cell death that is closely related to the pathophysiological processes underlying tumorigenesis, neurological diseases and other conditions. Moreover, ferroptosis is mediated via multiple regulatory pathways that may be targets for disease therapy. Recent studies have shown that the induction of ferroptosis is an effective way to kill sarcoma cells and reduce their resistance to chemotherapeutic drugs. Moreover, ferroptosis-related genes are related to the immune system, and their expression can be used to predict sarcoma prognosis. In this review, we describe the molecular mechanism underlying ferroptosis in detail, systematically summarize recent research progress with respect to ferroptosis application as a sarcoma treatment in various contexts, and point out gaps in the theoretical research on ferroptosis, challenges to its clinical application, potential resolutions of these challenges to promote ferroptosis as an efficient, reliable and novel method of clinical sarcoma treatment.
肉瘤是一种起源于间充质组织的恶性肿瘤。肉瘤的常见治疗方法是手术，并辅以放疗和化疗。然而，患者的5年生存率仅约为60%，且肉瘤细胞对化疗具有高度抗性。铁死亡是一种铁依赖性的非凋亡性程序性细胞死亡，与肿瘤发生、神经疾病和其他病症的病理生理过程密切相关。此外，铁死亡通过多种调控途径介导，这些途径可能成为疾病治疗的靶点。最近的研究表明，诱导铁死亡是杀死肉瘤细胞并降低其对化疗药物抗性的有效方法。此外，铁死亡相关基因与免疫系统有关，其表达可用于预测肉瘤的预后。在本综述中，我们详细描述了铁死亡的分子机制，系统总结了铁死亡在各种情况下作为肉瘤治疗方法的最新研究进展，并指出了铁死亡理论研究中的差距、其临床应用面临的挑战以及应对这些挑战的潜在解决方案，以推动铁死亡成为一种高效、可靠且新颖的临床肉瘤治疗方法。
