Zhang Gaosen, Fang Yi, Li Xiang, Zhang Zhen
Department of Ultrasound, First Affiliated Hospital of China Medical University, Shenyang, China.
Front Oncol. 2022 Sep 15;12:947530. doi: 10.3389/fonc.2022.947530. eCollection 2022.
Glioma is the most common malignant tumor of the central nervous system and resistance is easily developed to chemotherapy drugs during the treatment process, resulting in high mortality and short survival in glioma patients. Novel therapeutic approaches are urgently needed to improve the therapeutic efficacy of chemotherapeutic drugs and to improve the prognosis of patients with glioma. Ferroptosis is a novel regulatory cell death mechanism that plays a key role in cancer, neurodegenerative diseases, and other diseases. Studies have found that ferroptosis-related regulators are closely related to the survival of patients with glioma, and induction of ferroptosis can improve glioma resistance to chemotherapy drugs. Therefore, induction of tumor cell ferroptosis may be an effective therapeutic strategy for glioma. This review summarizes the relevant mechanisms of ferroptosis, systematically summarizes the key role of ferroptosis in the treatment of glioma and outlines the relationship between ferroptosis-related ncRNAs and the progression of glioma.
胶质瘤是中枢神经系统最常见的恶性肿瘤，在治疗过程中很容易对化疗药物产生耐药性，导致胶质瘤患者死亡率高、生存期短。迫切需要新的治疗方法来提高化疗药物的治疗效果，并改善胶质瘤患者的预后。铁死亡是一种新型的调节性细胞死亡机制，在癌症、神经退行性疾病和其他疾病中起关键作用。研究发现，铁死亡相关调节因子与胶质瘤患者的生存密切相关，诱导铁死亡可提高胶质瘤对化疗药物的耐药性。因此，诱导肿瘤细胞铁死亡可能是治疗胶质瘤的一种有效策略。本文综述了铁死亡的相关机制，系统总结了铁死亡在胶质瘤治疗中的关键作用，并概述了铁死亡相关非编码RNA与胶质瘤进展之间的关系。
