Yu Shangjiang, Jia Jinqiu, Zheng Jinyu, Zhou Yiyang, Jia Danyun, Wang Junlu
Department of Clinical Medicine, Wenzhou Medical University, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Pediatrics, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou, China.
Front Cell Dev Biol. 2021 Nov 16;9:789517. doi: 10.3389/fcell.2021.789517. eCollection 2021.
Ferroptosis is a new form of programmed cell death due to iron-dependent excess accumulation of lipid peroxides and differs from other programmed cell deaths in morphological and biochemical characteristics. The process of ferroptosis is precisely regulated by iron metabolism, lipid metabolism, amino acid metabolism, and numerous signaling pathways, and plays a complex role in many pathophysiological processes. Recent studies have found that ferroptosis is closely associated with the development and progression of many lung diseases, including acute lung injury, pulmonary ischemia-reperfusion injury, lung cancer, chronic obstructive pulmonary disease, and pulmonary fibrosis. Here, we present a review of the main regulatory mechanisms of ferroptosis and its research progress in the pathogenesis and treatment of lung diseases, with the aim of providing new ideas for basic and clinical research of lung-related diseases.
铁死亡是一种由于脂质过氧化物的铁依赖性过量积累而导致的新型程序性细胞死亡形式，在形态和生化特征上与其他程序性细胞死亡不同。铁死亡过程受到铁代谢、脂质代谢、氨基酸代谢以及众多信号通路的精确调控，并在许多病理生理过程中发挥复杂作用。最近的研究发现，铁死亡与许多肺部疾病的发生和发展密切相关，包括急性肺损伤、肺缺血再灌注损伤、肺癌、慢性阻塞性肺疾病和肺纤维化。在此，我们综述铁死亡的主要调控机制及其在肺部疾病发病机制和治疗方面的研究进展，旨在为肺部相关疾病的基础和临床研究提供新思路。
