Department of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stosza Gdańsk, 63, 80-308, Gdansk, Poland.
ChemMedChem. 2024 Jun 17;19(12):e202300672. doi: 10.1002/cmdc.202300672. Epub 2024 Apr 11.
Nanoparticles (NPs) of noble metals such as silver (Ag NPs) or gold (Au NPs) draw the attention of scientists looking for new compounds to use in medical applications. Scientists have used metal NPs because of their easy preparation, biocompatibility, ability to influence the shape and size or modification, and surface functionalization. However, to fully use their capabilities, both the benefits and their potential threats should be considered. One possibility to reduce the potential threat and thus prevent the extinction of their properties resulting from the agglomeration, they are covered with a neutral material, thus obtaining core-shell nanostructures that can be further modified and functionalized depending on the subsequent application. In this review, we focus on discussing the properties and applications of Ag NPs and Au NPs in the medical field such as the treatment of various diseases, drug carriers, diagnostics, and many others. In addition, the following review also discusses the use and potential applications of Ag@SiO and Au@SiO core-shell nanostructures, which can be used in cancer therapy and diagnosis, treatment of infections, or tissue engineering.
纳米粒子（NPs），如银（Ag NPs）或金（Au NPs）等贵金属的 NPs，吸引了科学家们的关注，他们正在寻找新的化合物用于医学应用。科学家们使用金属 NPs，是因为它们易于制备、具有生物相容性、能够影响形状和大小或进行修饰和表面功能化。然而，为了充分利用它们的能力，既要考虑到它们的益处，也要考虑到它们的潜在威胁。一种降低潜在威胁的可能性是，将它们用中性材料覆盖，从而获得核壳纳米结构，根据后续应用可以进一步对其进行修饰和功能化。在这篇综述中，我们重点讨论了 Ag NPs 和 Au NPs 在医学领域的性质和应用，例如治疗各种疾病、药物载体、诊断等。此外，本综述还讨论了 Ag@SiO 和 Au@SiO 核壳纳米结构的应用和潜在应用，它们可用于癌症治疗和诊断、感染治疗或组织工程。
