Mishra Priyanka, Bhargava Anuj, Nigam-Gupta Neha
Junior Resident, Department of Dentistry, Gandhi Medical College and Hamidia Hospital, Bhopal, M.P, India.
Associate Professor, Department of Dentistry, Gandhi Medical College and Hamidia, Hospital Bhopal, M.P, India.
J Clin Exp Dent. 2021 Apr 1;13(4):e342-e349. doi: 10.4317/jced.57635. eCollection 2021 Apr.
Gingivitis is one of the most prevalent oral disease in humans. The most important etiological factor of gingivitis is dental plaque. Plaque control procedures comprises of several mechanical and chemical methods. Many studies have advocated that chemical plaque control methods can be used successfully as an adjunct to mechanical plaque control procedures. Thus, the aim of this pilot study is to evaluate the effectiveness of two topical antimicrobial gels as an adjunct to mechanical plaque control over a period of 2 weeks in treatment of chronic gingivitis patients.
This is a single blind, two arm parallel design pilot clinical study including 60 systemically healthy patients with 1) chronic generalized gingivitis (MGI>1), 2) probing depth ≤ 3mm and 3) zero clinical attachment loss. The study participants were randomly assigned into two groups i.e., Group I- Chlorhexidine Gluconate (CHX) gel, Group II- combination gel of Chlorhexidine gluconate and Metronidazole (CHX-MTZ) gel. Clinical parameters viz. Gingival Index (GI) and Modified Sulcus bleeding index (MSBI) were recorded firstly at baseline after Scaling and Root Planing(SRP), and secondly at the end of the study period of two weeks. Intra and inter-group comparisons of clinical parameters were done using appropriate statistical tests.
There was high significant reduction in GI and MSBI scores at the end of 2 weeks period in both the groups. Further, combination gel of Group II (CHX+MTZ) was found to be statistically more effective as compared to Group I (CHX) used alone.
Our study suggests that Chemotherapeutic agents like CHX and combination CHX-MTZ Gel are clinically effective as adjunct to Scaling and Root Planning(SRP) in treatment of Chronic Gingivitis. Further, post statistical comparative analysis has proved CHX-MTZ combination gel regime to be more clinically effective than CHX gel used alone in treatment of Chronic Gingivitis as adjunct to SRP. Scaling and Root Planning (SRP), Chronic Gingivitis, Chlorhexidine Gluconate (CHX) gel, Combination (CHX+MTZ) Gel, Metronidazole (MTZ).
牙龈炎是人类最常见的口腔疾病之一。牙龈炎最重要的病因是牙菌斑。菌斑控制程序包括多种机械和化学方法。许多研究主张化学菌斑控制方法可成功用作机械菌斑控制程序的辅助手段。因此，本初步研究的目的是评估两种局部抗菌凝胶作为机械菌斑控制辅助手段，在治疗慢性牙龈炎患者两周时间内的有效性。
这是一项单盲、双臂平行设计的初步临床研究，纳入60名全身健康的患者，其具备以下条件：1）慢性广泛性牙龈炎（MGI>1），2）探诊深度≤3mm，3）临床附着丧失为零。研究参与者被随机分为两组，即第一组-葡萄糖酸氯己定（CHX）凝胶组，第二组-葡萄糖酸氯己定与甲硝唑联合凝胶（CHX-MTZ）组。临床参数，即牙龈指数（GI）和改良龈沟出血指数（MSBI），首先在龈上洁治和根面平整（SRP）后的基线时记录，其次在两周研究期结束时记录。使用适当的统计检验对临床参数进行组内和组间比较。
两组在2周结束时GI和MSBI评分均有高度显著降低。此外，发现第二组（CHX+MTZ）联合凝胶在统计学上比单独使用的第一组（CHX）更有效。
我们的研究表明，CHX等化疗药物以及CHX-MTZ联合凝胶作为龈上洁治和根面平整（SRP）的辅助手段，在治疗慢性牙龈炎方面临床有效。此外统计比较分析已证明，在作为SRP辅助手段治疗慢性牙龈炎时，CHX-MTZ联合凝胶方案比单独使用CHX凝胶在临床上更有效。龈上洁治和根面平整（SRP）、慢性牙龈炎、葡萄糖酸氯己定（CHX）凝胶、联合（CHX+MTZ）凝胶、甲硝唑（MTZ）
