Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding Hospital, Qingdao University, Yantai, China; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China.
Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China; The 2nd School of Clinical Medicine of Binzhou Medical University, Yantai, Shandong, China.
Respir Med. 2024 Apr-May;225:107580. doi: 10.1016/j.rmed.2024.107580. Epub 2024 Mar 12.
According to the concept of "united airway diseases", the airway is a single organ in which upper and lower airway diseases are commonly comorbid. A range of inflammatory factors have been found to play an important role in the chain reaction of upper and lower airway diseases. However, the amount of research on this concept remains limited. The underlying mechanism of the relationship between typical diseases of the united airway, such as asthma, allergic rhinitis, and chronic sinusitis, also needs to be further explored. This review highlights the interaction between upper and lower respiratory diseases gathered from epidemiological, histoembryology, neural mechanistic, microbiological, and clinical studies, revealing the relationship between the upper and lower respiratory tracts.
根据“统一气道疾病”的概念，气道是一个单一的器官，其中上下气道疾病通常并存。已经发现一系列炎症因子在上下气道疾病的连锁反应中起重要作用。然而，对于这一概念的研究仍然有限。联合气道的典型疾病（如哮喘、过敏性鼻炎和慢性鼻窦炎）之间关系的潜在机制也需要进一步探讨。本综述强调了从流行病学、组织胚胎学、神经机制学、微生物学和临床研究中收集到的上下呼吸道疾病之间的相互作用，揭示了上下呼吸道之间的关系。
