Department of Global Health, Faculty of Medicine & Health Sciences, Stellenbosch University, Stellenbosch.
School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Curr Opin Pulm Med. 2024 May 1;30(3):217-228. doi: 10.1097/MCP.0000000000001070. Epub 2024 Mar 15.
This review addresses the escalating global challenge of multidrug-resistant tuberculosis (MDR-TB) in Sub-Saharan Africa, with a focus on its complex comorbidity with HIV/AIDS. Emphasizing the urgency of the issue, the review aims to shed light on the unique healthcare landscape shaped by the convergence of high prevalence rates and intersecting complexities with HIV/AIDS in the region.
A notable increase in MDR-TB cases across Sub-Saharan Africa is attributed to challenges in timely diagnoses, treatment initiation, and patient treatment defaulting. The literature underscores the critical need for proactive measures to address diagnostic and treatment gaps associated with MDR-TB, particularly concerning its comorbidity with HIV/AIDS.
To effectively manage MDR-TB and its co-morbidity with HIV/AIDS, proactive screening programs are imperative. The review highlights the necessity of active follow-up strategies to ensure treatment adherence and reduce default rates, offering evidence-based insights for improved disease management in the region.
目的综述：本综述探讨了撒哈拉以南非洲地区耐多药结核病（MDR-TB）日益严重的问题，重点关注其与艾滋病毒/艾滋病的复杂合并症。鉴于问题的紧迫性，本综述旨在阐明该地区高患病率和与艾滋病毒/艾滋病相互交织的复杂性所塑造的独特医疗保健格局。
最近发现：撒哈拉以南非洲地区 MDR-TB 病例的显著增加归因于及时诊断、治疗开始和患者治疗中断方面的挑战。文献强调了采取积极措施解决与 MDR-TB 相关的诊断和治疗差距的迫切需要，特别是考虑到其与艾滋病毒/艾滋病的合并症。
总结：为了有效管理 MDR-TB 及其与 HIV/AIDS 的合并症，积极的筛查计划至关重要。本综述强调了积极的随访策略的必要性，以确保治疗依从性并降低违约率，为该地区改善疾病管理提供了循证见解。
