Dermatological Department (Department of Cosmetic Dermatology, Department of Surgery of Traditional Chinese Medicine), Baoji Hospital of Traditional Chinese Medicine, Baoji, Shaanxi, China.
Dermatological Department (Department of Cosmetic Dermatology, Department of Surgery of Traditional Chinese Medicine), Shaanxi University of Chinese Medicine, Xixian New Area, Shaanxi Province, China.
Medicine (Baltimore). 2024 Mar 15;103(11):e37329. doi: 10.1097/MD.0000000000037329.
To evaluate the impact of CO2 fractional laser combined with recombinant human epidermal growth factor (rhEGF) gel on skin barrier in acne scar patients. In a retrospective analysis, we examined 105 acne scar patients admitted between July 2018 and August 2021. Of these, 51 received only CO2 fractional laser (control group), while 54 underwent a combination of CO2 fractional laser and rhEGF gel (observation group). We assessed treatment efficacy, symptom relief, skin barrier parameters, pre- and posttreatment inflammatory factors, adverse reactions, posttreatment quality of life, and patient satisfaction. The observation group exhibited a higher overall response rate, significantly shorter wound healing, scab formation, and scab detachment times. Additionally, this group showed increased stratum corneum water content, decreased pH, and transdermal water loss (TEWL), and reduced hypersensitive C-reactive protein and interleukin-6 expression posttreatment. Quality of life scores were higher, with fewer adverse reactions and greater treatment satisfaction. Combining CO2 fractional laser with rhEGF gel markedly improves acne scar treatment efficacy, enhances skin barrier function, reduces inflammation, and elevates quality of life. Its safety profile supports its broader clinical adoption.
为了评估二氧化碳（CO2）点阵激光联合重组人表皮生长因子（rhEGF）凝胶对痤疮瘢痕患者皮肤屏障的影响。我们进行了一项回顾性分析，共纳入了 2018 年 7 月至 2021 年 8 月期间收治的 105 例痤疮瘢痕患者。其中，51 例仅接受 CO2 点阵激光治疗（对照组），54 例接受 CO2 点阵激光联合 rhEGF 凝胶治疗（观察组）。我们评估了治疗效果、症状缓解、皮肤屏障参数、治疗前后炎症因子、不良反应、治疗后生活质量和患者满意度。观察组总有效率更高，创面愈合、结痂形成和结痂脱落时间明显缩短。此外，该组治疗后角质层水分含量增加，pH 值和经皮水分丢失（TEWL）降低，超敏 C 反应蛋白和白细胞介素 6 的表达减少。生活质量评分更高，不良反应更少，治疗满意度更高。CO2 点阵激光联合 rhEGF 凝胶治疗明显提高了痤疮瘢痕的治疗效果，增强了皮肤屏障功能，减轻了炎症反应，提高了生活质量。其安全性良好，支持更广泛的临床应用。
