Saki Nasrin, Alavizadeh Sara, Parvizi Mohammad Mahdi, Kamali Mohammad
Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.
Lasers Med Sci. 2025 Apr 22;40(1):207. doi: 10.1007/s10103-025-04464-1.
Acne vulgaris is a common disease involving adolescents predominantly, which can lead to scar formation. This study aimed to compare the efficacy of fractional CO2 laser therapy, alone or combined with topical Timolol or insulin, for acne scar treatment, which has not been yet rigorously investigated.
In this Randomized Controlled Trial (RCT) conducted in 2024, we enrolled 30 subjects and randomly assigned them to groups A and B. Both groups received bilateral fractional CO2 laser therapy; one group received unilateral topical 0.5% Timolol Maleate, while the other received unilateral topical regular insulin. Scar severity was assessed using the Scale for Acne Scar Severity (SCAR-S), Acne Scar Assessment Scale (ASAS), and Goodman and Baron Quantitative Global Scarring Grading System (GBAQGS) before and after the therapy. Additionally, patients' quality of life was evaluated using the Dermatologic Life Quality Index (DLQI) questionnaire at the designated time points. Statistical analyses were conducted using the IBM ™ SPSS Statistics application (version 26.0).
The subjects consisted of 20 females and 10 males of Persian ethnicity, with a mean age of 32.20 years. Despite significant improvements in acne scar severity, and quality of life observed following fractional CO2 laser therapy alone and in combination with topical Timolol or insulin application, no significant differences existed between these treatment approaches. No adverse effect was seen during the study.
Fractional CO2 laser alone or its combination with topical Timolol or insulin mitigated acne scar severity and enhanced patients' quality of life, despite the absence of significant differences.
寻常痤疮是一种主要累及青少年的常见疾病，可导致瘢痕形成。本研究旨在比较分次二氧化碳激光治疗单独使用或联合外用噻吗洛尔或胰岛素治疗痤疮瘢痕的疗效，目前尚未对此进行严格研究。
在这项于2024年进行的随机对照试验（RCT）中，我们招募了30名受试者，并将他们随机分为A组和B组。两组均接受双侧分次二氧化碳激光治疗；一组接受单侧外用0.5%马来酸噻吗洛尔，另一组接受单侧外用常规胰岛素。在治疗前后，使用痤疮瘢痕严重程度量表（SCAR-S）、痤疮瘢痕评估量表（ASAS）和古德曼和巴伦定量整体瘢痕分级系统（GBAQGS）评估瘢痕严重程度。此外，在指定时间点使用皮肤病生活质量指数（DLQI）问卷评估患者的生活质量。使用IBM™ SPSS Statistics应用程序（版本26.0）进行统计分析。
受试者包括20名女性和10名男性波斯族裔，平均年龄为32.20岁。尽管单独使用分次二氧化碳激光治疗以及联合外用噻吗洛尔或胰岛素治疗后，痤疮瘢痕严重程度和生活质量均有显著改善，但这些治疗方法之间没有显著差异。研究期间未观察到不良反应。
尽管没有显著差异，但单独使用分次二氧化碳激光或其与外用噻吗洛尔或胰岛素联合使用均可减轻痤疮瘢痕严重程度并提高患者的生活质量。
