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ncRS:脓毒症中的非编码 RNA 资源。

ncRS: A resource of non-coding RNAs in sepsis.

机构信息

School of Computer and Software, Chengdu Neusoft University, Chengdu, China.

School of Computer and Software, Chengdu Neusoft University, Chengdu, China.

出版信息

Comput Biol Med. 2024 Apr;172:108256. doi: 10.1016/j.compbiomed.2024.108256. Epub 2024 Mar 11.

Abstract

Sepsis, a life-threatening condition triggered by the body's response to infection, presents a significant global healthcare challenge characterized by disarrayed host responses, widespread inflammation, organ impairment, and heightened mortality rates. This study introduces the ncRS database (http://www.ncrdb.cn), a meticulously curated repository housing 1144 experimentally validated non-coding RNAs (ncRNAs) intricately linked with sepsis. ncRS offers comprehensive RNA data, exhaustive experimental insights, and integrated annotations from diverse databases. This resource empowers researchers and clinicians to decipher ncRNAs' roles in sepsis pathogenesis, potentially identifying vital biomarkers for early diagnosis and prognosis, thus facilitating personalized treatments.

摘要

脓毒症是一种危及生命的疾病,由机体对感染的反应引发,是一个重大的全球医疗保健挑战,其特征是宿主反应紊乱、广泛炎症、器官损伤和死亡率升高。本研究介绍了 ncRS 数据库(http://www.ncrdb.cn),这是一个精心策划的存储库,其中包含 1144 个经过实验验证的与脓毒症密切相关的非编码 RNA(ncRNA)。ncRS 提供全面的 RNA 数据、详尽的实验见解以及来自不同数据库的综合注释。该资源使研究人员和临床医生能够破译 ncRNA 在脓毒症发病机制中的作用,有可能确定用于早期诊断和预后的重要生物标志物,从而促进个性化治疗。

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