Existing Civil Engineering structures have limited capability to adapt their configurations for new functions, non-stationary environments, or future reuse. Although origami principles provide capabilities of dense packaging and reconfiguration, existing origami systems have not achieved deployable metre-scale structures that can support large loads. Here, we established modular and uniformly thick origami-inspired structures that can deploy into metre-scale structures, adapt into different shapes, and carry remarkably large loads. This work first derives general conditions for degree-N origami vertices to be flat foldable, developable, and uniformly thick, and uses these conditions to create the proposed origami-inspired structures. We then show that these origami-inspired structures can utilize high modularity for rapid repair and adaptability of shapes and functions; can harness multi-path folding motions to reconfigure between storage and structural states; and can exploit uniform thickness to carry large loads. We believe concepts of modular and uniformly thick origami-inspired structures will challenge traditional practice in Civil Engineering by enabling large-scale, adaptable, deployable, and load-carrying structures, and offer broader applications in aerospace systems, space habitats, robotics, and more.