College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, China.
The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Wound Repair Regen. 2024 Jul-Aug;32(4):393-406. doi: 10.1111/wrr.13173. Epub 2024 Mar 17.
Skin injuries can have unexpected surfaces, leading to uneven wound surfaces and inadequate dressing contact with these irregular surfaces. This can decrease the dressing's haemostatic action and increase the healing period. This study recommends the use of sticky and flexible cryogel coverings to promote faster haemostasis and efficiently handle uneven skin wounds. Alginate cryogels have a fast haemostatic effect and shape flexibility due to their macroporous structure. The material demonstrates potent antibacterial characteristics and enhances skin adherence by adding grafted chitosan with gallic acid. In irregular defect wound models, cryogels can cling closely to uneven damage surfaces due to their amorphous nature. Furthermore, their macroporous structure allows for quick haemostasis by quickly absorbing blood and wound exudate. After giving the dressing a thorough rinse, its adhesive strength reduces and it is simple to remove without causing any damage to the wound. Cryogel demonstrated faster haemostasis than gauze in a wound model on a rat tail, indicating that it has considerable potential for use as a wound dressing in the biomedical area.
皮肤损伤可能具有意想不到的表面，导致伤口表面不均匀，敷料与这些不规则表面的接触不充分。这会降低敷料的止血作用，并延长愈合时间。本研究建议使用粘性和弹性的冷冻胶体覆盖物来促进更快的止血，并有效地处理不均匀的皮肤伤口。由于其大孔结构，藻酸盐冷冻胶体具有快速止血作用和形状灵活性。该材料通过添加接枝有没食子酸的壳聚糖表现出强大的抗菌特性，并增强皮肤附着性。在不规则缺损伤口模型中，由于其无定形性质，冷冻胶体可以紧密贴合不均匀的损伤表面。此外，其大孔结构允许通过快速吸收血液和伤口渗出物来快速止血。彻底冲洗敷料后，其粘性降低，易于去除，不会对伤口造成任何损伤。冷冻胶体在大鼠尾巴的伤口模型中比纱布更快地止血，表明它在生物医学领域作为伤口敷料具有很大的潜力。
