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利用运动校正布里渊显微镜对人体皮肤生物力学特性进行体内测量。

In vivo measurement of the biomechanical properties of human skin with motion-corrected Brillouin microscopy.

作者信息

Romodina Maria N, Parmar Asha, Singh Kanwarpal

机构信息

Max Planck Institute for the Science of Light, Staudtstr. 2, 91058 Erlangen, Germany.

Department of Physics, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany.

出版信息

Biomed Opt Express. 2024 Feb 20;15(3):1777-1784. doi: 10.1364/BOE.516032. eCollection 2024 Mar 1.

DOI:10.1364/BOE.516032
PMID:38495685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10942711/
Abstract

Biomechanical testing of human skin in vivo is important to study the aging process and pathological conditions such as skin cancer. Brillouin microscopy allows the all-optical, non-contact visualization of the mechanical properties of cells and tissues over space. Here, we use the combination of Brillouin microscopy and optical coherence tomography for motion-corrected, depth-resolved biomechanical testing of human skin in vivo. We obtained two peaks in the Brillouin spectra for the epidermis, the first at 7 GHz and the second near 9-10 GHz. The experimentally measured Brillouin frequency shift of the dermis is lower compared to the epidermis and is 6.8 GHz, indicating the lower stiffness of the dermis.

摘要

人体皮肤的体内生物力学测试对于研究衰老过程和诸如皮肤癌等病理状况非常重要。布里渊显微镜能够对细胞和组织的力学特性进行全光学、非接触式的空间可视化。在此，我们将布里渊显微镜与光学相干断层扫描相结合，用于对人体皮肤进行体内运动校正、深度分辨的生物力学测试。我们在表皮的布里渊光谱中获得了两个峰，第一个在7吉赫兹，第二个在9至10吉赫兹附近。与表皮相比，真皮的实验测量布里渊频移较低，为6.8吉赫兹，这表明真皮的硬度较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/10942711/70461a3650b6/boe-15-3-1777-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/10942711/bf6f9f327f5d/boe-15-3-1777-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/10942711/90832a1994ff/boe-15-3-1777-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/10942711/70461a3650b6/boe-15-3-1777-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/10942711/bf6f9f327f5d/boe-15-3-1777-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/10942711/90832a1994ff/boe-15-3-1777-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca1b/10942711/70461a3650b6/boe-15-3-1777-g003.jpg

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本文引用的文献

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