Guler Ridvan, Agacayak Kamil-Serkan
DDS, MSC, Dicle University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Diyarbakir, Turkey.
DDS, PHD, Dicle University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Diyarbakir, Turkey.
J Clin Exp Dent. 2024 Feb 1;16(2):e172-e177. doi: 10.4317/jced.61240. eCollection 2024 Feb.
HT is a systemic disease that presents with persistent high blood pressure, which has become an important health problem due to its cause of serious complications and high prevalence in the community. Aim: This study aims to examine the bone mineral density (BMD) of male patients using different groups of antihypertensive drugs for long terms with dental volumetric tomography.
The study was carried out using the data of patients who applied to the Dicle University Faculty of Dentistry and underwent the Dental Volumetric Tomography (DVT) scan for any reason. The patients included in the study were divided into 4 groups according to their antihypertensive use; Group 1: 60 patients who never used hypertensive medication before, Group 2: 60 patients who received Calcium Channel Blocker treatment for over 5 years, Group 3: 60 patients who received Beta Blocker treatment for over 5 years, Group 4: 60 patients who received ACE inhibitor treatment for over 5 years. Radiomorphometric measurements were made on the DVT data and the DVT-Mandibular Index Inferior, DVT-Cortical Index, Hounsfield Unit-Cortical and Hounsfield Unit-Spongios values were calculated. The Kruskal-Wallis test, the Mann Whitney test with Bonferroni correction, the One-Way ANOVA and Post-Hoc Tukey test were used in the study.
A significant increase in DVT-CI and a significant decrease in HU-CORTIKAL, HU-SPONGIOS and DVT-MII values were observed in the patients using Calcium Channel Blocker medication. These findings pointed to osteoporosis. In addition, no statistically significant difference in the use of antihypertensive drugs in the Beta Blocker and ACE Inhibitor groups compared to the Control Group were found.
The long term use of Calcium Channel Blocker group antihypertensive drugs should be considered as a risk factor for osteoporosis in men. Antihypertensive drug, Osteoporosis, Radiomorphometric index, Mandible, Dental volumetric tomography, Bone mineral density.
高血压是一种表现为持续性高血压的全身性疾病，由于其会引发严重并发症且在社区中患病率高，已成为一个重要的健康问题。目的：本研究旨在通过牙科容积断层扫描检查长期使用不同组抗高血压药物的男性患者的骨密度（BMD）。
本研究使用了申请到迪克莱大学牙科学院并因任何原因接受牙科容积断层扫描（DVT）的患者数据。纳入研究的患者根据其抗高血压药物使用情况分为4组；第1组：60名以前从未使用过高血压药物的患者，第2组：60名接受钙通道阻滞剂治疗超过5年的患者，第3组：60名接受β受体阻滞剂治疗超过5年的患者，第4组：60名接受血管紧张素转换酶抑制剂治疗超过5年的患者。对DVT数据进行放射形态计量学测量，并计算DVT-下颌骨下部指数、DVT-皮质指数、亨氏单位-皮质和亨氏单位-松质骨值。本研究使用了Kruskal-Wallis检验、经Bonferroni校正的Mann Whitney检验、单因素方差分析和事后Tukey检验。
在使用钙通道阻滞剂药物的患者中，观察到DVT-CI显著增加，HU-皮质骨、HU-松质骨和DVT-MII值显著降低。这些发现表明存在骨质疏松症。此外，与对照组相比，β受体阻滞剂组和血管紧张素转换酶抑制剂组在使用抗高血压药物方面未发现统计学上的显著差异。
长期使用钙通道阻滞剂组抗高血压药物应被视为男性骨质疏松症的一个危险因素。抗高血压药物、骨质疏松症、放射形态计量学指数、下颌骨、牙科容积断层扫描、骨密度。
