Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Excellence Specialist Medicine, University of Palermo, Palermo, Italy.
COVID-19 Vaccination Center, Hospital Unit of Clinical Epidemiology and Cancer Registry, University Hospital of Palermo, Palermo, Italy.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2327229. doi: 10.1080/21645515.2024.2327229. Epub 2024 Mar 18.
With the pandemic, there has been a global reduction in influenza virus circulation, with WHO reporting, during 2021/22 season, laboratory testing positivity rate for influenza of less than 3%. Influenza surveillance systems anticipated a peak of influenza cases in the Northern Hemisphere during 2022/2023 season and the Italian Ministry of Health recommended the routinary co-administration of influenza with bivalent COVID-19 vaccines for the 2022/2023 season. At the Vaccination Hub of the University Hospital (UH) of Palermo, more than 700 subjects received influenza and COVID-19 booster doses in co-administration, during the 2021/2022 season. A cross-sectional study analyzing attitudes and factors associated with adherence to influenza and COVID-19 seasonal vaccines co-administration was conducted at the Vaccination Hub of the UH of Palermo, from October to December 2022. Among the 1,263 respondents, 74.7% ( = 944) received the co-administration of seasonal influenza and COVID-19 vaccines. The main reason reported for accepting it was confidence in the recommendations of the Health Ministry (41.3%). At the multivariable analysis, subjects aged ≤ 59 y old (AdjOR: 2.48; CIs95%: 1.89-3.65), male (AdjOR: 1.51; CIs95%: 1.27-1.75), Health-care professionals (HCPs) (AdjOR: 1.66; CIs95%: 1.08-2.57) and those who received co-administration during 2021/2022 (AdjOR: 41.6; CIs95%: 25.5-67.9) were significantly more prone to receive co-administration during 2022/23 season. From data obtained, the role of HCPs in accepting and then promoting co-administration of COVID-19 and influenza vaccines is crucial, as well as receiving co-administration in the previous season that represented the main drive for accepting it in the following seasons, supporting safety and effectiveness of this procedure.
随着大流行的出现，全球流感病毒传播减少，世界卫生组织报告称，在 2021/22 季节，流感实验室检测阳性率低于 3%。流感监测系统预计，2022/2023 季节北半球的流感病例将达到高峰，意大利卫生部建议在 2022/2023 季节常规联合使用流感和二价 COVID-19 疫苗。在巴勒莫大学医院（UH）的疫苗接种中心，在 2021/2022 季节，有 700 多名受试者接受了流感和 COVID-19 加强剂量的联合接种。2022 年 10 月至 12 月，在巴勒莫 UH 的疫苗接种中心进行了一项横断面研究，分析了与接受流感和 COVID-19 季节性疫苗联合接种相关的态度和因素。在 1263 名受访者中，74.7%（944 人）接受了季节性流感和 COVID-19 疫苗的联合接种。接受联合接种的主要原因是对卫生部建议的信任（41.3%）。在多变量分析中，年龄≤59 岁的受试者（调整后的优势比：2.48；95%可信区间：1.89-3.65）、男性（调整后的优势比：1.51；95%可信区间：1.27-1.75）、卫生保健专业人员（HCPs）（调整后的优势比：1.66；95%可信区间：1.08-2.57）和在 2021/2022 年接受联合接种的受试者（调整后的优势比：41.6；95%可信区间：25.5-67.9）在 2022/23 季节更倾向于接受联合接种。从获得的数据来看，HCPs 在接受并随后推广 COVID-19 和流感疫苗联合接种方面发挥着至关重要的作用，在之前的季节接受联合接种是接受下一个季节联合接种的主要动力，支持了这一程序的安全性和有效性。
