State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
ACS Appl Mater Interfaces. 2024 Mar 27;16(12):14421-14433. doi: 10.1021/acsami.3c16577. Epub 2024 Mar 18.
Injectable antibacterial and osteoinductive hydrogels have received considerable attention for promoting bone regeneration owing to their versatile functionalities. However, a current hydrogel with antibacterial, osteoinductive, and antioxidant properties by a facile method for periodontitis treatment is still missing. To overcome this issue, we designed an injectable hydrogel system (GPM) composed of gelatin, TiCT MXene nanosheets, and poly-l-lysine using a simple enzymatic cross-linking technique. Physicochemical characterization demonstrated that the GPM hydrogel matrix exhibited excellent stability, moderate tissue adhesion ability, and good mechanical behavior. The GPM hydrogels significantly inhibited the growth of , scavenged reactive oxygen species, attenuated inflammatory responses, and enhanced bone tissue regeneration. Intriguingly, the arrangement of the junctional epithelium, alveolar bone volume, and alveolar bone height in the GPM-treated periodontal disease group recovered to that of the healthy group. Therefore, our injectable hydrogel system with versatile functions may serve as an excellent tissue scaffold for the treatment of periodontitis.
可注射的抗菌和骨诱导水凝胶因其多功能性而受到相当大的关注，以促进骨再生。然而，目前仍然缺乏一种具有抗菌、骨诱导和抗氧化特性的简易方法的水凝胶，用于治疗牙周炎。为了克服这个问题，我们使用简单的酶交联技术设计了一种由明胶、TiCT MXene 纳米片和聚-l-赖氨酸组成的可注射水凝胶系统（GPM）。物理化学特性表明，GPM 水凝胶基质具有优异的稳定性、适度的组织粘附能力和良好的机械性能。GPM 水凝胶显著抑制了 的生长，清除了活性氧，减轻了炎症反应，促进了骨组织再生。有趣的是，GPM 处理的牙周病组的结合上皮排列、牙槽骨体积和牙槽骨高度恢复到健康组的水平。因此，我们具有多功能的可注射水凝胶系统可能是治疗牙周炎的一种极好的组织支架。
