Wang Xingxin, Dong Tiantian, Li Xuhao, Yu Wenyan, Jia Zhixia, Liu Yuanxiang, Yang Jiguo
School of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Heliyon. 2024 Mar 6;10(6):e27437. doi: 10.1016/j.heliyon.2024.e27437. eCollection 2024 Mar 30.
As the second most common neurodegenerative disease globally, Parkinson's disease (PD) affects millions of people worldwide. In recent years, the scientific publications related to PD biomarker research have exploded, reflecting the growing interest in unraveling the complex pathophysiology of PD. In this study, we aim to use various bibliometric tools to identify key scientific concepts, detect emerging trends, and analyze the global trends and development of PD biomarker research.The research encompasses various stages of biomarker development, including exploration, identification, and multi-modal research. MOVEMENT DISORDERS emerged as the leading journal in terms of publications and citations. Key authors such as Mollenhauer and Salem were identified, while the University of Pennsylvania and USA stood out in collaboration and research output. NEUROSCIENCES emerged as the most important research direction. Key biomarker categories include α-synuclein-related markers, neurotransmitter-related markers, inflammation and immune system-related markers, oxidative stress and mitochondrial function-related markers, and brain imaging-related markers. Furthermore, future trends in PD biomarker research focus on exosomes and plasma biomarkers, miRNA, cerebrospinal fluid biomarkers, machine learning applications, and animal models of PD. These trends contribute to early diagnosis, disease progression monitoring, and understanding the pathological mechanisms of PD.
作为全球第二常见的神经退行性疾病，帕金森病（PD）影响着全球数百万人。近年来，与PD生物标志物研究相关的科学出版物呈爆炸式增长，这反映出人们对揭示PD复杂病理生理学的兴趣日益浓厚。在本研究中，我们旨在使用各种文献计量工具来识别关键科学概念、检测新出现的趋势，并分析PD生物标志物研究的全球趋势和发展情况。该研究涵盖了生物标志物开发的各个阶段，包括探索、识别和多模态研究。《运动障碍》在出版物数量和引用次数方面成为领先期刊。确定了如莫伦豪尔和塞勒姆等关键作者，而宾夕法尼亚大学和美国在合作和研究产出方面表现突出。神经科学成为最重要的研究方向。关键生物标志物类别包括α-突触核蛋白相关标志物、神经递质相关标志物、炎症和免疫系统相关标志物、氧化应激和线粒体功能相关标志物以及脑成像相关标志物。此外，PD生物标志物研究的未来趋势集中在外泌体和血浆生物标志物、微小RNA、脑脊液生物标志物、机器学习应用以及PD动物模型。这些趋势有助于早期诊断、疾病进展监测以及理解PD的病理机制。
