Li Xuefeng, Chen Chunhai, Pan Ting, Zhou Xue, Sun Xiaozhou, Zhang Ziyang, Wu Dalong, Chen Xinhua
Changchun University of Chinese Medicine, Changchun, China.
The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Front Aging Neurosci. 2024 Jan 17;16:1335550. doi: 10.3389/fnagi.2024.1335550. eCollection 2024.
Non-motor symptoms are prevalent among individuals with Parkinson's disease (PD) and seriously affect patient quality of life, even more so than motor symptoms. In the past decade, an increasing number of studies have investigated non-motor symptoms in PD. The present study aimed to comprehensively analyze the global literature, trends, and hotspots of research investigating non-motor symptoms in PD through bibliometric methods. Studies addressing non-motor symptoms in the Web of Science Core Collection (WoSCC), published between January 2013 and December 2022, were retrieved. Bibliometric methods, including the R package "Bibliometrix," VOS viewer, and CiteSpace software, were used to investigate and visualize parameters, including yearly publications, country/region, institution, and authors, to collate and quantify information. Analysis of keywords and co-cited references explored trends and hotspots. There was a significant increase in the number of publications addressing the non-motor symptoms of PD, with a total of 3,521 articles retrieved. The United States was ranked first in terms of publications ( = 763) and citations ( = 11,269), maintaining its leadership position among all countries. King's College London (United Kingdom) was the most active institution among all publications ( = 133) and K Ray Chaudhuri was the author with the most publications ( = 131). published the most articles, while was the most cited journal. Reference explosions have shown that early diagnosis, biomarkers, novel magnetic resonance imaging techniques, and deep brain stimulation have become research "hotspots" in recent years. Keyword clustering revealed that alpha-synuclein is the largest cluster for PD. The keyword heatmap revealed that non-motor symptoms appeared most frequently ( = 1,104), followed by quality of life ( = 502), dementia ( = 403), and depression ( = 397). Results of the present study provide an objective, comprehensive, and systematic analysis of these publications, and identifies trends and "hot" developments in this field of research. This work will inform investigators worldwide to help them conduct further research and develop new therapies.
非运动症状在帕金森病（PD）患者中普遍存在，甚至比运动症状更严重地影响患者的生活质量。在过去十年中，越来越多的研究对PD的非运动症状进行了调查。本研究旨在通过文献计量学方法全面分析关于PD非运动症状研究的全球文献、趋势和热点。检索了2013年1月至2022年12月期间发表在科学引文索引核心合集（WoSCC）中关于非运动症状的研究。使用包括R包“Bibliometrix”、VOS viewer和CiteSpace软件在内的文献计量学方法来调查和可视化参数，包括年度出版物、国家/地区、机构和作者，以整理和量化信息。对关键词和共被引参考文献的分析探索了趋势和热点。关于PD非运动症状的出版物数量显著增加，共检索到3521篇文章。美国在出版物数量（=763）和被引频次（=11269）方面排名第一，在所有国家中保持领先地位。伦敦国王学院（英国）是所有出版物中最活跃的机构（=133），K Ray Chaudhuri是发表文章最多的作者（=131）。 发表的文章最多，而 是被引频次最高的期刊。参考文献激增表明，早期诊断、生物标志物、新型磁共振成像技术和深部脑刺激已成为近年来的研究“热点”。关键词聚类显示，α-突触核蛋白是PD最大的聚类。关键词热图显示，非运动症状出现的频率最高（=1104），其次是生活质量（=502）、痴呆（=403）和抑郁（=397）。本研究结果对这些出版物进行了客观、全面和系统的分析，并确定了该研究领域的趋势和“热门”发展。这项工作将为全球的研究人员提供信息，帮助他们进行进一步的研究和开发新的疗法。
