Liu Gaihong, Liu Ningning, Xu Yingxue, Su Fan
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Anesthesiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
Medicine (Baltimore). 2025 Jul 4;104(27):e43180. doi: 10.1097/MD.0000000000043180.
This study analyzes the research hotspots and future directions of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis.
Relevant literature was searched using the Web of Science database and analyzed using econometric tools such as CiteSpace and VOSviewer.
A total of 145 articles were included in this study, involving 317 research institutions in 31 countries and regions. Acta Neuropathologica is a prominent journal in terms of issuance and influence, and countries such as the United States and Japan, as well as institutions such as the University of Pennsylvania, occupy an important position in the research. The keywords cover various aspects such as disease characteristics and gene mutations; highly-cited literature focuses on TDP-43 protein and C9orf72 gene mutations. Research hotspots include TDP-43 protein disease-driven pathomechanisms, RNA-related studies, clinical manifestations of the disease and genetic studies, etc. In recent years, research focus has shifted to RNA, C9orf72 gene and so on.
To our knowledge, this study is the first econometric evaluation of the FTLD-ALS literature, and although there are limitations such as relying on the number of documents and citation relationships, and a single source of data, it provides a valuable reference for research in this field and helps to promote subsequent research.
本研究分析额颞叶变性（FTLD）和肌萎缩侧索硬化症的研究热点及未来方向。
使用科学网数据库检索相关文献，并使用CiteSpace和VOSviewer等计量工具进行分析。
本研究共纳入145篇文章，涉及31个国家和地区的317个研究机构。《神经病理学学报》在发文量和影响力方面是一本突出的期刊，美国、日本等国家以及宾夕法尼亚大学等机构在该研究中占据重要地位。关键词涵盖疾病特征和基因突变等各个方面；高被引文献聚焦于TDP - 43蛋白和C9orf72基因突变。研究热点包括TDP - 43蛋白病驱动的发病机制、RNA相关研究、疾病临床表现及遗传学研究等。近年来，研究重点已转向RNA、C9orf72基因等。
据我们所知，本研究是对FTLD - ALS文献的首次计量评估，尽管存在依赖文献数量和引用关系以及单一数据来源等局限性，但它为该领域的研究提供了有价值的参考，并有助于推动后续研究。
