Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
School of Dentistry, The University of Queensland, Herston, Queensland, Australia.
Periodontol 2000. 2024 Oct;96(1):95-111. doi: 10.1111/prd.12558. Epub 2024 Mar 19.
It has long been considered that the oral microbiome is tightly connected to oral health and that dysbiotic changes can be detrimental to the occurrence and progression of dysplastic oral mucosal lesions or oral cancer. Improved understanding of the concepts of microbial dysbiosis together with advances in high-throughput molecular sequencing of these pathologies have charted in greater microbiological detail the nature of their clinical state. This review discusses the bacteriome and mycobiome associated with oral mucosal lesions, oral candidiasis, and oral squamous cell carcinoma, aiming to delineate the information available to date in pursuit of advancing diagnostic and prognostic utilities for oral medicine.
长期以来，人们一直认为口腔微生物组与口腔健康密切相关，菌群失调的变化可能对发育不良的口腔黏膜病变或口腔癌的发生和发展有害。对微生物失调概念的深入理解以及这些病变高通量分子测序技术的进步，更详细地描述了其临床状态的微生物特征。本综述讨论了与口腔黏膜病变、口腔念珠菌病和口腔鳞状细胞癌相关的细菌组和真菌组，旨在阐述目前可用于推进口腔医学诊断和预后的信息。
