Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
BMC Cardiovasc Disord. 2024 Mar 19;24(1):168. doi: 10.1186/s12872-024-03747-9.
Insulin resistance (IR) may participate in the pathogenesis of hypertension by mediating low-grade systemic inflammation. The triglycerides-glucose (TyG) index has recently been suggested as a reliable alternative biochemical marker of IR compared with traditional methods. Herein, we speculated TyG index may also be associated with hypertension.
Data of adults were extracted from the China Health and Nutrition Survey (CHNS) in 2009-2015 in this retrospective cohort study. The TyG index was calculated using the formula: TyG = Ln [fasting triglycerides (mg/dL) ×fasting glucose (mg/dL)/2]. Associations between TyG index and hypertension were evaluated by univariate and multivariate logistic regression analyses with odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses of age and gender were also performed. In addition, we assessed the interaction effect between TyG index and body mass index (BMI) on hypertension in participants with different age and gender.
Among 3,413 eligible participants, 1,627 (47.67%) developed hypertension. The average TyG index in hypertension group and non-hypertension group was 8.58 and 8.39 respectively. After adjusting for covariates, we found that compared with participants with TyG index ≤ 8.41 (median value), those who had higher TyG index seemed to have higher odds of hypertension [OR = 1.17, 95%CI: (1.01-1.37)]. Similarly, this association was also discovered in participants who aged ≤ 65 years old [OR = 1.19, 95%CI: (1.01-1.39)] or were female [OR = 1.35, 95%CI: (1.10-1.65)]. Additionally, there was a potential additive interaction effect between obesity and TyG index on hypertension.
High TyG index was associated with high odds of hypertension in general population in China, but the causal relationship between them needed further exploration.
胰岛素抵抗（IR）可能通过介导低度全身炎症参与高血压的发病机制。与传统方法相比，甘油三酯-葡萄糖（TyG）指数最近被认为是一种可靠的替代胰岛素抵抗的生化标志物。在这里，我们推测 TyG 指数也可能与高血压有关。
本回顾性队列研究从中国健康与营养调查（CHNS）2009-2015 年的数据中提取了成年人的数据。TyG 指数通过以下公式计算：TyG=Ln[空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2]。使用单变量和多变量逻辑回归分析评估 TyG 指数与高血压之间的关联，并用比值比（ORs）和 95%置信区间（CIs）表示。还进行了年龄和性别亚组分析。此外，我们评估了 TyG 指数与体重指数（BMI）在不同年龄和性别的参与者中对高血压的交互作用。
在 3413 名合格参与者中，有 1627 名（47.67%）发生了高血压。高血压组和非高血压组的平均 TyG 指数分别为 8.58 和 8.39。在调整了协变量后，我们发现与 TyG 指数≤8.41（中位数）的参与者相比，TyG 指数较高的参与者似乎具有更高的高血压发病风险[OR=1.17，95%CI：（1.01-1.37）]。同样，在年龄≤65 岁的参与者[OR=1.19，95%CI：（1.01-1.39）]或女性[OR=1.35，95%CI：（1.10-1.65）]中也发现了这种关联。此外，肥胖和 TyG 指数之间对高血压存在潜在的附加交互作用。
在中国一般人群中，高 TyG 指数与高血压的高发病风险相关，但它们之间的因果关系需要进一步探讨。
