ENT & Audiology Department, University Hospital of Ferrara, Via Aldo Moro 8, 44124, Cona, FE, Italy.
Gruppo Otorinolaringologico Della Romagna, Primus Medical Center of Forlì, Via Punta di Ferro 2/C, 47122, Forlì, FC, Italy.
J Med Case Rep. 2024 Mar 20;18(1):172. doi: 10.1186/s13256-024-04425-2.
Cystadenoma of the salivary glands is a rare benign clinical condition affecting both major and minor salivary glands equally. It constitutes approximately 2% of total neoplasms and 4.2-4.7% of benign formations in minor salivary glands. Typically presenting as a slow-growing, painless neoplasm, it can be distinguished from Cystadenolymphoma (Whartin's Tumor) by the absence of lymphoid elements in histological examination. While mostly located in the oral cavity and oropharynx, it can also be found in sinonasal mucosa, and rare cases have been identified in the larynx.
A 75-year-old Caucasian woman presented to the ear, nose, and throat department with complaints of dysphonia and headaches persisting for several months. Dysphonia had developed months after an unspecified vocal cord surgery elsewhere. Flexible laryngoscopy identified a left-sided cystic swelling affecting the supraglottic space, leading to respiratory obstruction and dysphonia. Head and neck computed tomography confirmed a 1.9 × 1.7 cm bilobed cystic mass originating from the left Morgagni ventricle. Microlaryngoscopy with CO laser excision and biopsy revealed a histopathological diagnosis of oncocytic papillary cystadenoma. Post-surgery, the patient fully recovered from dysphonia, with no significant complications noted. Long-term clinical surveillance was advised to detect potential recurrences promptly.
Ectopic minor salivary gland tumors, both benign and malignant, should be taken into consideration as potential differential diagnosis for any swelling arising within the upper digestive tract mucosa. Ears, nose, and throat clinical examination completed by videolaryngoscopy can easily point out the location of the mass. Imaging is mandatory for differential diagnosis and for surgical planning. Surgical excision can provide both diagnosis and definitive cure.
唾液腺囊腺瘤是一种罕见的良性临床疾病，影响大、小唾液腺，发生率相等。它约占所有肿瘤的 2%，占小唾液腺良性肿瘤的 4.2-4.7%。通常表现为缓慢生长、无痛的肿瘤，通过组织学检查中无淋巴样成分可与囊性腺淋巴瘤（沃辛瘤）相鉴别。虽然大多数位于口腔和口咽，但也可发生于鼻腔-鼻窦黏膜，喉部罕见。
一名 75 岁白人女性因声音嘶哑和持续数月的头痛就诊耳鼻喉科。声音嘶哑是在其他地方进行声带手术数月后出现的。软性喉镜检查发现左侧影响声门上区的囊性肿胀，导致呼吸阻塞和声音嘶哑。头颈部 CT 证实起源于左侧 Morgagni 室的 1.9×1.7cm 分叶囊性肿块。显微镜喉镜下 CO2 激光切除和活检显示为嗜酸细胞乳头状囊腺瘤的组织病理学诊断。手术后，患者完全恢复声音嘶哑，无明显并发症。建议长期临床监测以及时发现潜在的复发。
上消化道黏膜任何肿胀都应考虑为异位小唾液腺肿瘤（良性和恶性）的潜在鉴别诊断。喉镜完成的耳鼻喉科临床检查可轻松指出肿块的位置。影像学检查是鉴别诊断和手术计划所必需的。手术切除可提供诊断和明确的治疗。
