Xiang Chenyang, Zhang Yuxuan, Guo Weisheng, Liang Xing-Jie
Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
Acta Pharm Sin B. 2020 Feb;10(2):239-248. doi: 10.1016/j.apsb.2019.11.003. Epub 2019 Nov 6.
Nowadays, nanotechnology is revolutionizing the approaches to different fields from manufacture to health. Carbon nanotubes (CNTs) as promising candidates in nanomedicine have great potentials in developing novel entities for central nervous system pathologies, due to their excellent physicochemical properties and ability to interface with neurons and neuronal circuits. However, most of the studies mainly focused on the drug delivery and bioimaging applications of CNTs, while neglect their application prospects as therapeutic drugs themselves. At present, the relevant reviews are not available yet. Herein we summarized the latest advances on the biomedical and therapeutic applications of CNTs and for neurological diseases treatments as inherent therapeutic drugs. The biological mechanisms of CNTs-mediated bio-medical effects and potential toxicity of CNTs were also intensely discussed. It is expected that CNTs will exploit further neurological applications on disease therapy in the near future.
如今，纳米技术正在彻底改变从制造到健康等不同领域的研究方法。碳纳米管（CNTs）作为纳米医学中有前景的候选材料，因其优异的物理化学性质以及与神经元和神经回路相互作用的能力，在开发用于中枢神经系统疾病的新型实体方面具有巨大潜力。然而，大多数研究主要集中在碳纳米管的药物递送和生物成像应用上，而忽视了它们作为治疗药物本身的应用前景。目前，尚无相关综述。在此，我们总结了碳纳米管作为固有治疗药物在生物医学和治疗应用方面的最新进展，以及在神经疾病治疗中的应用。我们还深入讨论了碳纳米管介导的生物医学效应的生物学机制以及碳纳米管的潜在毒性。预计在不久的将来，碳纳米管将在疾病治疗方面开拓更多的神经学应用。
