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J Med Case Rep. 2021 Nov 4;15(1):548. doi: 10.1186/s13256-021-03163-z.
2
Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition.评估氟西汀介导的CYP2D6抑制机制。
Pharmaceutics. 2021 Jan 23;13(2):148. doi: 10.3390/pharmaceutics13020148.
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Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis.广泛性焦虑障碍的药物治疗：系统评价和网络荟萃分析。
Lancet. 2019 Feb 23;393(10173):768-777. doi: 10.1016/S0140-6736(18)31793-8. Epub 2019 Jan 31.
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Pharmacological interventions targeting anhedonia in patients with major depressive disorder: A systematic review.针对重性抑郁障碍患者快感缺失的药物干预：系统评价。
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:109-117. doi: 10.1016/j.pnpbp.2019.01.002. Epub 2019 Jan 3.
5
Dextromethorphan abuse leading to assault, suicide, or homicide.右美沙芬滥用导致攻击、自杀或杀人。
J Forensic Sci. 2012 Sep;57(5):1388-94. doi: 10.1111/j.1556-4029.2012.02133.x. Epub 2012 Apr 26.
6
Dextromethorphan-induced serotonin syndrome.右美沙芬诱发的5-羟色胺综合征。
Clin Toxicol (Phila). 2008 Sep;46(8):771-3. doi: 10.1080/15563650701668625.
7
Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents.蜂蜜、右美沙芬及不治疗对咳嗽儿童及其父母夜间咳嗽和睡眠质量的影响。
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8
Dextromethorphan in Wisconsin drivers.威斯康星州司机体内的右美沙芬。
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9
A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium.一名双相情感障碍患者在服用氟西汀和锂盐治疗期间，因滥用止咳药右美沙芬引发血清素综合征的病例。
Gen Hosp Psychiatry. 2006 Jan-Feb;28(1):78-80. doi: 10.1016/j.genhosppsych.2005.06.008.
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Adolescent abuse of dextromethorphan.青少年滥用右美沙芬。
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右美沙芬诱发的潜在血清素综合征导致他杀和自杀。

Potential Dextromethorphan-Induced Serotonin Syndrome Leading to Homicide and Suicide.

作者信息

Pavelka Matthew M, Kohr Roland

出版信息

Acad Forensic Pathol. 2024 Jan 30;14(1):21-25. doi: 10.1177/19253621231224531. eCollection 2024 Mar.

DOI:10.1177/19253621231224531
PMID:38505641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10947710/
Abstract

Limited case reports have been published regarding serotonin syndrome due to the combined effects of supratherapeutic levels of dextromethorphan and selective serotonin reuptake inhibitor. We report a case of an adolescent with postmortem findings suggestive of a diagnosis of serotonin syndrome-induced psychosis associated with a double homicide and suicide. Postmortem toxicology of the suicide victim was remarkable for elevated serotonergic metabolites of fluoxetine and dextromethorphan in a 14-year-old male.

摘要

关于右美沙芬超治疗剂量与选择性5-羟色胺再摄取抑制剂联合作用导致血清素综合征，仅有有限的病例报告发表。我们报告了一例青少年病例，尸检结果提示诊断为血清素综合征所致精神病，该病例与一起双重凶杀及自杀事件有关。一名14岁男性自杀受害者的尸检毒理学结果显示，其体内氟西汀和右美沙芬的血清素能代谢产物水平升高。