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巴西帕拉州圣塔伦县麻风病的流行病学、临床和地理特征:有效控制和针对性干预的见解。

Epidemiological, clinical, and geographical characterization of Leprosy in the County of Santarém-Pará: Insights for effective control and targeted intervention.

机构信息

Department Health at the University of the State of Pará, Belém, Brazil.

Department of Health at the Federal University of Western Pará, Belém, Brazil.

出版信息

PLoS Negl Trop Dis. 2024 Mar 20;18(3):e0012063. doi: 10.1371/journal.pntd.0012063. eCollection 2024 Mar.

Abstract

Leprosy is an infectious disease characterized by slow and chronic evolution, caused by Mycobacterium leprae and or Mycobacterium lepromatosis, an intracellular alcohol-acid-resistant (BAAR) bacillus. The objective of this study was to provide an epidemiological, clinical, and geographic characterization of leprosy in the city of Santarém-Pará during the period 2011-2020. A cross-sectional, descriptive, and quantitative approach was used, employing maps and tables to illustrate clinical and epidemiological variables, including: sex, age, race, area of residence, operational classification, clinical form, number of skin lesions, number of affected nerves, and health units. During the analyzed period, 581 cases of leprosy were diagnosed, resulting in the following cumulative incidence rates: male (60%); age over 15 years (94%); urban area (73%); multibacillary (74%); borderline form (46%); skin lesions greater than 5 (34%); and no nerves affected (68%). In the urban perimeter, a higher cumulative incidence of cases was observed in the central area with 133 cases. However, the health unit reporting the largest number of cases belonged to the southern area, specifically the Basic Health Unit of Nova República, with 48 cases. This study highlights the need to characterize the nuances of leprosy and its variability within the urban environment, according to different areas. Further research is essential to inform the implementation of public policies aimed at addressing the population with the highest vulnerability index, thereby reducing leprosy rates in Santarém.

摘要

麻风病是一种由麻风分枝杆菌或麻风分枝杆菌引起的传染性疾病,其特征为缓慢而慢性的演变,具有抗酸(BAAR)特性的细胞内杆菌。本研究的目的是对 2011-2020 年期间圣塔伦市麻风病的流行病学、临床和地理特征进行描述。采用了横断面、描述性和定量的方法,使用图表来阐述临床和流行病学变量,包括:性别、年龄、种族、居住区域、操作分类、临床形式、皮肤损伤数量、受影响的神经数量和卫生单位。在分析期间,诊断出 581 例麻风病病例,累积发病率如下:男性(60%);年龄超过 15 岁(94%);城区(73%);多菌型(74%);边缘型(46%);皮肤损伤大于 5 处(34%);无神经受累(68%)。在城区周边,中心区域的累积发病率较高,有 133 例病例。然而,报告病例数量最多的卫生单位属于南部地区,特别是新共和国基础卫生单位,有 48 例。本研究强调了需要根据不同区域的特点来描述麻风病及其在城市环境中的变化。进一步的研究对于制定针对高脆弱性指数人群的公共政策至关重要,从而降低圣塔伦的麻风病发病率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5acd/10984465/3d9f2eb70cf1/pntd.0012063.g001.jpg

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