Medical Laboratory Techniques Department, Al-Maarif University College, Anbar, Iraq.
Department of Pharmacy (Pharmaceutics), Baghdad College of Medical Sciences, Baghdad, Iraq.
Cell Biochem Funct. 2024 Mar;42(2):e3971. doi: 10.1002/cbf.3971.
Autophagy, as a highly conserved cellular process, participates in cellular homeostasis by degradation and recycling of damaged organelles and proteins. Besides, autophagy has been evidenced to play a dual role through cancer initiation and progression. In the early stage, it may have a tumor-suppressive function through inducing apoptosis and removing damaged cells and organelles. However, late stages promote tumor progression by maintaining stemness features and induction of chemoresistance. Therefore, identifying and targeting molecular mechanisms involved in autophagy is a potential therapeutic strategy for human cancers. Multiple transcription factors (TFs) are involved in the regulation of autophagy by modulating the expression of autophagy-related genes (ATGs). In addition, a wide array of long noncoding RNAs (lncRNAs), a group of regulatory ncRNAs, have been evidenced to regulate the function of these autophagy-related TFs through tumorigenesis. Subsequently, the lncRNAs/TFs/ATGs axis shows great potential as a therapeutic target for human cancers. Therefore, this review aimed to summarize new findings about the role of lncRNAs in regulating autophagy-related TFs with therapeutic perspectives.
自噬作为一种高度保守的细胞过程，通过降解和回收受损的细胞器和蛋白质参与细胞内稳态。此外，自噬已被证明通过启动和促进肿瘤进展来发挥双重作用。在早期，它可能通过诱导细胞凋亡和清除受损细胞和细胞器来发挥肿瘤抑制功能。然而，晚期通过维持干性特征和诱导化疗耐药性来促进肿瘤进展。因此，鉴定和靶向自噬相关分子机制是治疗人类癌症的一种潜在策略。多种转录因子（TFs）通过调节自噬相关基因（ATGs）的表达来参与自噬的调节。此外，大量长链非编码 RNA（lncRNAs），一类调节性 ncRNAs，已被证明通过肿瘤发生来调节这些自噬相关 TF 的功能。随后，lncRNA/TF/ATG 轴作为治疗人类癌症的潜在靶点显示出巨大的潜力。因此，本综述旨在总结 lncRNA 在调节与治疗相关的自噬 TF 方面的新发现。
