Department of Thoracic Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518055, China.
Biochim Biophys Acta Rev Cancer. 2023 Sep;1878(5):188932. doi: 10.1016/j.bbcan.2023.188932. Epub 2023 Jun 16.
Autophagy is well-known as an internal catabolic process that is evolutionarily conserved and performs the key biological function in maintaining cellular homeostasis. It is tightly controlled by several autophagy-related (ATG) proteins, which are closely associated with many types of human cancers. However, what has remained controversial is the janus roles of autophagy in cancer progression. Interestingly, the biological function of long non-coding RNAs (lncRNAs) in autophagy has been gradually understood in different types of human cancers. More recently, numerous studies have demonstrated that several lncRNAs may regulate some ATG proteins and autophagy-related signaling pathways to either activate or inhibit the autophagic process in cancer. Thus, in this review, we summarize the latest advance in the knowledge of the complicated relationships between lncRNAs and autophagy in cancer. Also, the in-depth dissection of the lncRNAs-autophagy-cancers axis involved in this review would shed new light on discovery of more potential cancer biomarkers and therapeutic targets in the future.
自噬是一种众所周知的细胞内分解代谢过程，在进化上是保守的，在维持细胞内稳态方面发挥着关键的生物学功能。它受几种自噬相关（ATG）蛋白的严密调控，这些蛋白与多种人类癌症密切相关。然而，自噬在癌症进展中的双重作用仍然存在争议。有趣的是，长链非编码 RNA（lncRNA）在不同类型人类癌症中的自噬作用的生物学功能逐渐被理解。最近，许多研究表明，一些 lncRNA 可能通过调节一些 ATG 蛋白和自噬相关信号通路来激活或抑制癌症中的自噬过程。因此，在这篇综述中，我们总结了 lncRNA 与癌症中自噬之间复杂关系的最新进展。此外，对本综述中涉及的 lncRNA-自噬-癌症轴的深入剖析，将为未来发现更多潜在的癌症生物标志物和治疗靶点提供新的思路。
