Department of Occupational Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Epidemiology and Biostatistics, Faculty of Health, Qom University of Medical Sciences, Qom, Iran.
Toxicol Lett. 2024 May 1;395:26-39. doi: 10.1016/j.toxlet.2024.03.005. Epub 2024 Mar 20.
This cross-sectional study was performed to assess whether systemic inflammatory indices, including systemic inflammation response index (SIRI), systemic immune‑inflammation index (SII), and aggregate index of systemic inflammation (AISI), can be considered as possible inflammatory markers in silica-exposed workers with no diagnosis of silicosis. We studied 371 non-silicotic workers exposed to respirable silica dust (RSD) and 1422 reference workers. The workers' exposure to RSD were assessed and the inflammatory indices were compared between subgroups of the exposed workers based on the severity and duration of exposure. Correlations between inflammatory indices and the pulmonary function parameters were investigated. Also, the receiver operating characteristic (ROC) curve and Youden index were used to determine the cut-off values of the SII, SIRI, and AISI. Significant dose-response relationships were observed between duration of exposure and all indices except monocytes and LMR. No significant interaction was observed between duration of exposure to RSD and smoking. Borderline significant correlations were observed between AISI and SIRI with forced expiratory volume (FEV1) and FEV1 to forced vital capacity (FVC) ratio. Higher AUCs were obtained for SII and AISI, respectively. The cut-off values for these biomarkers to be considered abnormal were > 348.48 for SII, > 183.78 for AISI, and > 0.768 for SIRI. Overall, the present study showed for the first time, that SII, AISI, and SIRI might be considered as available, easy-to-obtain, and non-expensive markers of inflammation in non-silicotic workers with a long duration of exposure to RSD who are at risk of developing silicosis in subsequent years.
本横断面研究旨在评估全身性炎症指标，包括全身炎症反应指数（SIRI）、全身免疫炎症指数（SII）和全身性炎症综合指数（AISI），是否可作为无矽肺诊断的矽尘暴露工人的潜在炎症标志物。我们研究了 371 名无矽肺的暴露于可吸入性二氧化硅粉尘（RSD）的工人和 1422 名对照工人。评估了工人的 RSD 暴露情况，并根据暴露的严重程度和时间长短，比较了暴露工人亚组之间的炎症指标。研究了炎症指标与肺功能参数之间的相关性。还使用了受试者工作特征（ROC）曲线和 Youden 指数来确定 SII、SIRI 和 AISI 的截断值。除单核细胞和 LMR 外，暴露时间与所有指标之间均观察到显著的剂量-反应关系。未观察到 RSD 暴露时间与吸烟之间存在显著的交互作用。AISI 和 SIRI 与用力呼气量（FEV1）和 FEV1 与用力肺活量（FVC）比值之间存在边缘显著相关性。SII 和 AISI 的 AUC 较高。这些生物标志物被认为异常的截断值分别为>SII>348.48、>AISI>183.78 和>SIRI>0.768。总体而言，本研究首次表明，SII、AISI 和 SIRI 可能被认为是有价值的、易于获得的、且非昂贵的炎症标志物，适用于长期暴露于 RSD 且有罹患矽肺风险的非矽肺工人。
