Wang H, Xie K X, Chen L L, Cao Y, Shen Z J, Lyu J, Yu C Q, Sun D J Y, Pei P, Zhong J M, Yu M
Department of Chronic and Non-communicable Disease Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
Department of Chronic and Non-communicable Disease Control and Prevention, Tongxiang County Center for Disease Control and Prevention, Tongxiang 314599, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2024 Mar 10;45(3):325-330. doi: 10.3760/cma.j.cn112338-20230904-00125.
To explore the prospective associations between physical activity and incident ischemic stroke in adults. Data of China Kadoorie Biobank study in Tongxiang of Zhejiang were used. After excluding participants with cancers, strokes, heart diseases and diabetes at baseline study, a total of 53 916 participants aged 30-79 years were included in the final analysis. The participants were divided into 5 groups according to the quintiles of their physical activity level. Cox proportional hazard regression models was used to calculate the hazard ratios () for the analysis on the association between baseline physical activity level and risk for ischemic stroke. The total physical activity level in the participants was (30.63±15.25) metabolic equivalent (MET)-h/d, and it was higher in men [(31.04±15.48) MET-h/d] than that in women [(30.33±15.07) MET-h/d] (<0.001). In 595 526 person-years of the follow-up (average 11.4 years), a total of 1 138 men and 1 082 women were newly diagnosed with ischemic stroke. Compared to participants with the lowest physical activity level (<16.17 MET-h/d), after adjusting for socio-demographic factors, lifestyle, BMI, waist circumference, and SBP, the s for the risk for ischemic stroke in those with moderate low physical activity level (16.17-24.94 MET-h/d), moderate physical activity level (24.95-35.63 MET-h/d), moderate high physical activity level (35.64-43.86 MET-h/d) and the highest physical activity level (≥43.87 MET-h/d) were 0.93 (95%: 0.83-1.04), 0.87 (95%: 0.76-0.98), 0.82 (95%: 0.71-0.95) and 0.76 (95%: 0.64-0.89), respectively. Improving physical activity level has an effect on reducing the risk for ischemic stroke.
探索成年人身体活动与缺血性卒中发病之间的前瞻性关联。使用了中国浙江桐乡卡多尔生物银行研究的数据。在排除基线研究时患有癌症、中风、心脏病和糖尿病的参与者后，最终分析纳入了53916名年龄在30 - 79岁之间的参与者。参与者根据其身体活动水平的五分位数分为5组。采用Cox比例风险回归模型计算风险比（HR），以分析基线身体活动水平与缺血性卒中风险之间的关联。参与者的总身体活动水平为（30.63±15.25）代谢当量（MET）-小时/天，男性[（31.04±15.48）MET-小时/天]高于女性[（30.33±15.07）MET-小时/天]（P<0.001）。在595526人年的随访（平均11.4年）中，共有1138名男性和1082名女性新诊断为缺血性卒中。与身体活动水平最低（<16.17 MET-小时/天）的参与者相比，在调整了社会人口学因素、生活方式、体重指数、腰围和收缩压后，身体活动水平为中度低（16.17 - 24.94 MET-小时/天）、中度（24.95 - 35.63 MET-小时/天）、中度高（35.64 - 43.86 MET-小时/天）和最高（≥43.87 MET-小时/天）的参与者发生缺血性卒中风险的HR分别为0.93（95%置信区间：0.83 - 1.04）、0.87（95%置信区间：0.76 - 0.98）、0.82（95%置信区间：0.71 - 0.95）和0.76（95%置信区间：0.64 - 0.89）。提高身体活动水平对降低缺血性卒中风险有作用。
