Department of Gastroenterology, The Second Affiliated Hospital, JiangXi Medical College, Nanchang University, Nanchang, China.
J Cancer Res Clin Oncol. 2024 Mar 22;150(3):150. doi: 10.1007/s00432-024-05656-y.
Morbidity and mortality rates of Digestive System Cancers (DSC) continue to pose human lives and health. Nuclear factor erythroid 2-like protein 3 (NFE2L3) is aberrantly expressed in DSC. This study aimed to explore the clinical value and underlying mechanisms of NFE2L3 as a novel biomarker in DSC.
We utilized data from databases and clinical gastric cancer specimens to validate the aberrant expression level of NFE2L3 and further assessed the clinical value of NFE2L3. To investigate the potential molecular mechanism of NFE2L3, we analyzed the correlation of NFE2L3 with immune molecular mechanisms, constructed PPI network, performed GO analysis and KEGG analysis, and finally explored the biological function of NFE2L3 in gastric cancer cells.
NFE2L3 expression is up-regulated in DSC and has both prognostic and diagnostic value. NFE2L3 correlates with various immune mechanisms, PPI network suggests proteins interacting with NFE2L3, GSEA analysis suggests potential molecular mechanisms for NFE2L3 to play a role in cancer promotion, and in vitro cellular experiments also confirmed the effect of NFE2L3 on the biological function of gastric cancer cells.
Our study confirms the aberrant expression and molecular mechanisms of NFE2L3 in DSC, indicating that NFE2L3 could serve as a novel biomarker for diagnosis and prognosis of DSC.
消化系统癌症（DSC）的发病率和死亡率继续对人类的生命和健康构成威胁。核因子红细胞 2 样蛋白 3（NFE2L3）在 DSC 中异常表达。本研究旨在探讨 NFE2L3 作为 DSC 新型生物标志物的临床价值及其潜在机制。
我们利用数据库和临床胃癌标本数据来验证 NFE2L3 的异常表达水平，并进一步评估 NFE2L3 的临床价值。为了探讨 NFE2L3 的潜在分子机制，我们分析了 NFE2L3 与免疫分子机制的相关性，构建了 PPI 网络，进行了 GO 分析和 KEGG 分析，最后探讨了 NFE2L3 在胃癌细胞中的生物学功能。
NFE2L3 在 DSC 中表达上调，具有预后和诊断价值。NFE2L3 与多种免疫机制相关，PPI 网络提示与 NFE2L3 相互作用的蛋白，GSEA 分析提示 NFE2L3 发挥作用的潜在分子机制促进癌症，体外细胞实验也证实了 NFE2L3 对胃癌细胞生物学功能的影响。
本研究证实了 NFE2L3 在 DSC 中的异常表达及其分子机制，表明 NFE2L3 可作为 DSC 诊断和预后的新型生物标志物。
