两种新的倍半萜糖苷化合物来自 L. var. Mast. Makino 的花萼。
Two new sesquiterpenoid glycoside compounds from the calyces of L. var. Mast. Makino.
机构信息
College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710049, China.
出版信息
J Asian Nat Prod Res. 2024 Jul;26(7):795-802. doi: 10.1080/10286020.2024.2323202. Epub 2024 Mar 21.
Two new sesquiterpenoid glycosides, 8 ()-eudesmane-1,3,11 (13)-triene-2-one -12---D-glucopyranoside () and dmetelisproside B (), together with ten known compounds (-) were isolated from calyces of L. var. (Mast.) Makino (PAF). Their structures were unambiguously elucidated through HR-ESI-MS, UV, IR, and NMR spectral data. Compounds , , and exhibited DPPH scavenging ability with IC values of 33.69 ± 6.65, 6.29 ± 0.06, and 25.66 ± 3.06 M, respectively. Additionally, and demonstrated weak α-glucosidase inhibition activity with IC values of 250.9 ± 6.60 and 347.6 ± 2.48 M, respectively.
从 L. var. (Mast.) Makino (PAF) 的花萼中分离得到了两种新的倍半萜糖苷，8 ()-桉叶烷-1,3,11 (13)-三烯-2-酮-12---D-吡喃葡萄糖苷 () 和 dmetelisproside B ()，以及十种已知化合物 (-)。通过高分辨电喷雾质谱（HR-ESI-MS）、紫外（UV）、红外（IR）和核磁共振（NMR）光谱数据，明确鉴定了它们的结构。化合物 、 、和 具有 DPPH 清除能力，其 IC 值分别为 33.69 ± 6.65、6.29 ± 0.06 和 25.66 ± 3.06 M。此外， 和 对 α-葡萄糖苷酶表现出较弱的抑制活性，其 IC 值分别为 250.9 ± 6.60 和 347.6 ± 2.48 M。
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