从（Mast.）Makino 变种石蒜中分离得到的两个新石蒜碱衍生物。
Two new physalin derivatives from L. var. (Mast.) Makino.
机构信息
Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin, PR China.
Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, PR China.
出版信息
Nat Prod Res. 2021 Jan;35(2):203-206. doi: 10.1080/14786419.2019.1619724. Epub 2019 May 29.
Two new physalin derivatives named 7-ethoxyl-isophysalin C () and 3-ethoxyl-2,3-dihydro-4,7-didehydrophysalin B () were isolated from L. var. (Mast.) Makino. Their structures were determined by extensive NMR-spectroscopic analysis and HRESIMS data. Compounds and were tested for their cytotoxicity against PC-3 cancer cell lines. Compound showed apparent moderate with IC values of 8.26 M, whereas compound exhibited no cytotoxicity against PC-3 cancer cell lines.
从 L. var. (Mast.) Makino 中分离得到了两个新的石蒜裂碱衍生物，分别命名为 7-乙氧基异石蒜裂碱 C () 和 3-乙氧基-2,3-二氢-4,7-二去氢石蒜裂碱 B ()。通过核磁共振波谱分析和高分辨电喷雾质谱 (HRESIMS) 数据确定了它们的结构。对 和 进行了对 PC-3 癌细胞系的细胞毒性测试。化合物 表现出明显的中等活性，IC 值为 8.26 μM，而化合物 对 PC-3 癌细胞系没有细胞毒性。
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