Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin, PR China.
Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, PR China.
Nat Prod Res. 2021 Jan;35(2):203-206. doi: 10.1080/14786419.2019.1619724. Epub 2019 May 29.
Two new physalin derivatives named 7-ethoxyl-isophysalin C () and 3-ethoxyl-2,3-dihydro-4,7-didehydrophysalin B () were isolated from L. var. (Mast.) Makino. Their structures were determined by extensive NMR-spectroscopic analysis and HRESIMS data. Compounds and were tested for their cytotoxicity against PC-3 cancer cell lines. Compound showed apparent moderate with IC values of 8.26 M, whereas compound exhibited no cytotoxicity against PC-3 cancer cell lines.
从 L. var. (Mast.) Makino 中分离得到了两个新的石蒜裂碱衍生物，分别命名为 7-乙氧基异石蒜裂碱 C () 和 3-乙氧基-2,3-二氢-4,7-二去氢石蒜裂碱 B ()。通过核磁共振波谱分析和高分辨电喷雾质谱 (HRESIMS) 数据确定了它们的结构。对 和 进行了对 PC-3 癌细胞系的细胞毒性测试。化合物 表现出明显的中等活性，IC 值为 8.26 μM，而化合物 对 PC-3 癌细胞系没有细胞毒性。
