School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China.
Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Nat Prod Res. 2022 Oct;36(20):5206-5212. doi: 10.1080/14786419.2021.1924713. Epub 2021 Jun 28.
Two new physalins, 7α-hydroxy-5-deoxy-4-dehydrophysalin IX () and 5-deoxy-4-dehydrophysalin IX (), together with six known compounds, luteolin (), luteolin-7--glucoside (), neoechinulin A (), 3-(4-hydroxy-3-methoxyphenyl)--(4-methylphenyl)-2-propenamide (), physalin D () and blumenol A () were isolated from L. var. (Mast.) Makino. Their structures were elucidated by NMR spectroscopic analysis, HR-ESI-MS, X-ray crystallographic data analysis and comparison with the known compounds. Among them, compounds and were isolated from the genus for the first time. Compound exhibited weak NAD(P)H: quinone reductase (QR) inducing activity.
从 L. var. (Mast.) Makino 中分离得到两个新的 physalins，7α-羟基-5-去氧-4-去氢 physalin IX () 和 5-去氧-4-去氢 physalin IX ()，以及六个已知化合物，木犀草素 ()、木犀草素-7-O--葡萄糖苷 ()、新绵马素 A ()、3-(4-羟基-3-甲氧基苯基)-()-(4-甲基苯基)-2-丙烯酰胺 ()、physalin D () 和 blumenol A ()。通过 NMR 光谱分析、高分辨率电喷雾电离质谱 (HR-ESI-MS)、X 射线晶体学数据分析以及与已知化合物的比较，确定了它们的结构。其中，化合物 和 是首次从属中分离得到的。化合物 表现出较弱的 NAD(P)H：醌还原酶 (QR) 诱导活性。
