Li Yunbin, Li Xiaosong, Li Jian
Department of Thoracic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Front Oncol. 2024 Mar 7;14:1360638. doi: 10.3389/fonc.2024.1360638. eCollection 2024.
Lung cancer is a highly prevalent malignant tumor worldwide, with high incidence and death rates. Recently, there has been increasing recognition of the role of ferroptosis, a unique cell death mechanism, in lung cancer. This review aims to summarize the current research progress on the relationship between ferroptosis and lung cancer. It also provides a comprehensive analysis of the regulatory processes of ferroptosis in various stages, including epigenetics, transcription, post-transcription, translation, and post-translation. Additionally, the review explores the dual nature of ferroptosis in lung cancer progression, which presents interesting therapeutic possibilities. On one hand, ferroptosis can promote the escape of immune surveillance and reduce the efficacy of treatment in the early stages of tumors. On the other hand, it can counter drug resistance, enhance radiosensitivity, and promote immunotherapy. The article also discusses various combination treatment strategies based on the mechanism of ferroptosis. Overall, this review offers a holistic perspective on the role of ferroptosis in the onset, progression, and treatment of lung cancer. It aims to contribute to future research and clinical interventions in this field.
肺癌是全球高度流行的恶性肿瘤，发病率和死亡率都很高。最近，一种独特的细胞死亡机制——铁死亡在肺癌中的作用得到了越来越多的认识。这篇综述旨在总结铁死亡与肺癌关系的当前研究进展。它还全面分析了铁死亡在各个阶段的调控过程，包括表观遗传学、转录、转录后、翻译和翻译后阶段。此外，该综述探讨了铁死亡在肺癌进展中的双重性质，这呈现出有趣的治疗可能性。一方面，铁死亡可促进免疫逃逸并降低肿瘤早期的治疗效果。另一方面，它可以对抗耐药性、增强放射敏感性并促进免疫治疗。本文还讨论了基于铁死亡机制的各种联合治疗策略。总体而言，这篇综述对铁死亡在肺癌发生、发展和治疗中的作用提供了全面的视角。它旨在为该领域的未来研究和临床干预做出贡献。
