基于肽的癌症疫苗的合成递送制剂的设计与评估

Song Kefan, Pun Suzie H

Department of Bioengineering, University of Washington, USA.

Molecular Engineering & Sciences Institute, University of Washington, USA.

BME Front. 2024 Mar 21;5:0038. doi: 10.34133/bmef.0038. eCollection 2024.

With the recent advances in neoantigen identification, peptide-based cancer vaccines offer substantial potential in the field of immunotherapy. However, rapid clearance, low immunogenicity, and insufficient antigen-presenting cell (APC) uptake limit the efficacy of peptide-based cancer vaccines. This review explores the barriers hindering vaccine efficiency, highlights recent advancements in synthetic delivery systems, and features strategies for the key delivery steps of lymph node (LN) drainage, APC delivery, cross-presentation strategies, and adjuvant incorporation. This paper also discusses the design of preclinical studies evaluating vaccine efficiency, including vaccine administration routes and murine tumor models.

随着新抗原鉴定技术的最新进展，基于肽的癌症疫苗在免疫治疗领域具有巨大潜力。然而，快速清除、低免疫原性以及抗原呈递细胞（APC）摄取不足限制了基于肽的癌症疫苗的疗效。本综述探讨了阻碍疫苗效率的障碍，强调了合成递送系统的最新进展，并介绍了淋巴结（LN）引流、APC递送、交叉呈递策略和佐剂掺入等关键递送步骤的策略。本文还讨论了评估疫苗效率的临床前研究设计，包括疫苗给药途径和小鼠肿瘤模型。