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本文引用的文献

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Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens.老年人的多药治疗、不适当处方和撤药:从性别视角看。
Lancet Healthy Longev. 2021 May;2(5):e290-e300. doi: 10.1016/S2666-7568(21)00054-4.
2
Fifteen-year trajectories of multimorbidity and polypharmacy in Dutch primary care-A longitudinal analysis of age and sex patterns.15 年荷兰初级保健中多种疾病和多种药物治疗的轨迹:年龄和性别模式的纵向分析。
PLoS One. 2022 Feb 25;17(2):e0264343. doi: 10.1371/journal.pone.0264343. eCollection 2022.
3
Polypharmacy occurrence and the related risk of premature death among older adults in Denmark: A nationwide register-based cohort study.丹麦老年人多药治疗的发生情况和与过早死亡相关的风险:一项基于全国登记的队列研究。
PLoS One. 2022 Feb 23;17(2):e0264332. doi: 10.1371/journal.pone.0264332. eCollection 2022.
4
Polypharmacy in Polish Older Adult Population-A Cross-Sectional Study: Results of the PolSenior Project.波兰老年人群体中的多药治疗:波兰老年人项目的横断面研究结果。
Int J Environ Res Public Health. 2022 Jan 18;19(3):1030. doi: 10.3390/ijerph19031030.
5
Gender and racial inequalities in the access to and the use of Brazilian health services.巴西卫生服务获取和使用方面的性别和种族不平等。
Cien Saude Colet. 2021 Sep;26(9):4021-4032. doi: 10.1590/1413-81232021269.05732021. Epub 2021 May 2.
6
Longevity leap: mind the healthspan gap.长寿飞跃:关注健康寿命差距。
NPJ Regen Med. 2021 Sep 23;6(1):57. doi: 10.1038/s41536-021-00169-5.
7
Patient and physician factors contributing to polypharmacy among older patients.导致老年患者多重用药的患者因素和医生因素。
Curr Med Res Opin. 2022 Jan;38(1):123-130. doi: 10.1080/03007995.2021.1982683. Epub 2021 Oct 6.
8
Health insurance coverage in Brazil: analyzing data from the National Health Survey, 2013 and 2019.巴西的医疗保险覆盖情况:2013 年和 2019 年全国健康调查数据分析。
Cien Saude Colet. 2021 Jun 14;26(suppl 1):2529-2541. doi: 10.1590/1413-81232021266.1.43532020. eCollection 2021.
9
Prevalence of Polypharmacy and Risks of Potentially Inappropriate Medication Use in the Older Population in a Developing Country: A Systematic Review and Meta-Analysis.发展中国家老年人群多重用药的患病率及潜在不适当用药风险:一项系统评价与荟萃分析
Gerontology. 2022;68(2):136-145. doi: 10.1159/000516075. Epub 2021 May 11.
10
Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences.老年人多药治疗:定义、流行病学和后果的叙述性综述。
Eur Geriatr Med. 2021 Jun;12(3):443-452. doi: 10.1007/s41999-021-00479-3. Epub 2021 Mar 10.

巴西老年人的多重用药情况:与社会人口学因素及医疗服务可及性的关联

Polypharmacy among older adults in Brazil: Association with sociodemographic factors and access to health services.

作者信息

Ramos Karina Alves, Boing Alexandra Crispim, Andrade Juliana Mara, Bof de Andrade Fabíola

机构信息

René Rachou Institute, Oswaldo Cruz Foundation (FIOCRUZ), Belo Horizonte, MG, Brazil.

Federal University of Santa Catarina, Florianopolis, SC, Brazil.

出版信息

Dialogues Health. 2022 Nov 13;1:100078. doi: 10.1016/j.dialog.2022.100078. eCollection 2022 Dec.

DOI:10.1016/j.dialog.2022.100078
PMID:38515895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10953922/
Abstract

BACKGROUND

Polypharmacy is common among older adults and is of public health concern, since pharmacological therapy influences the quality of care for older individuals. Few studies have addressed its prevalence and correlates in low or middle-income countries. Objective: To evaluate the prevalence of polypharmacy in a representative sample of the Brazilian older population and its association with sociodemographic conditions and factors related to access to health services.

METHODS

Cross-sectional study with data from the last National Health Survey, conducted in 2019. The dependent variable was polypharmacy (five or more medications) and independent variables were: sociodemographic characteristics, general health conditions and access to health services indicator.

RESULTS

The prevalence of polypharmacy was 19.2%. Polypharmacy was higher among those aged 80 years and over compared to those aged 60-69 years (prevalence ratio (PR) 1.47; 95% CI: 1.30; 1.66); individuals with complete elementary education (PR 1.35; 95% CI: 1.13; 1.60) versus those who did not go to school; with 3+ chronic diseases (PR 11.14; 95% CI: 7.94; 15.63); those with limitations in basic activities of daily life (PR 1.49; 95% CI: 1.35; 1.63) and possession of private medical health insurance (PR 1.32; 95% CI 1.19; 1.46). Being in a marital relationship was inversely associated with polypharmacy (PR 0.88; 95% CI: 0.80; 0.96).

CONCLUSION

Polypharmacy affects a significant proportion of the Brazilian older population and is associated with sociodemographic factors and access to health services.

摘要

背景

多重用药在老年人中很常见,这是一个公共卫生问题,因为药物治疗会影响老年人的护理质量。很少有研究探讨其在低收入或中等收入国家的患病率及相关因素。目的:评估巴西老年人群代表性样本中多重用药的患病率及其与社会人口学状况和获得卫生服务相关因素的关联。

方法

采用2019年进行的上一次全国健康调查数据进行横断面研究。因变量为多重用药(服用五种或更多药物),自变量为:社会人口学特征、总体健康状况和获得卫生服务指标。

结果

多重用药的患病率为19.2%。80岁及以上人群的多重用药率高于60 - 69岁人群(患病率比值(PR)为1.47;95%置信区间:1.30;1.66);完成小学教育的个体(PR为1.35;95%置信区间:1.13;1.60)与未上学的个体相比;患有3种及以上慢性病的个体(PR为11.14;95%置信区间:7.94;15.63);日常生活基本活动受限的个体(PR为1.49;95%置信区间:1.35;1.63)以及拥有私人医疗保险的个体(PR为1.32;95%置信区间1.19;1.46)。处于婚姻关系与多重用药呈负相关(PR为0.88;95%置信区间:0.80;0.96)。

结论

多重用药影响了相当比例的巴西老年人群,且与社会人口学因素和获得卫生服务有关。