National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.
Front Endocrinol (Lausanne). 2022 Aug 1;13:885650. doi: 10.3389/fendo.2022.885650. eCollection 2022.
Diabetes mellitus (DM) is an endocrine disorder characterized by a relative or absolute lack of insulin due to the dysfunction or destruction of β-cells. DM is one of the fastest growing challenges to global health in the 21 century and places a tremendous burden on affected individuals and their families and countries. Although insulin and antidiabetic drugs have been used to treat DM, a radical cure for the disease is unavailable. The pathogenesis of DM remains unclear. Emerging roles of circular RNAs (circRNAs) in DM have become a subject of global research. CircRNAs have been verified to participate in the onset and progression of DM, implying their potential roles as novel biomarkers and treatment tools. In the present review, we briefly introduce the characteristics of circRNAs. Next, we focus on specific roles of circRNAs in type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus and diabetes-associated complications.
糖尿病（DM）是一种内分泌紊乱，其特征是由于β细胞的功能障碍或破坏而导致相对或绝对缺乏胰岛素。DM 是 21 世纪全球健康面临的增长最快的挑战之一，给患者及其家庭和国家带来了巨大负担。尽管胰岛素和抗糖尿病药物已被用于治疗 DM，但该疾病尚无根治方法。DM 的发病机制仍不清楚。环状 RNA（circRNAs）在 DM 中的新兴作用已成为全球研究的课题。已经验证 circRNAs 参与 DM 的发病和进展，表明它们作为新型生物标志物和治疗工具的潜在作用。在本综述中，我们简要介绍了 circRNAs 的特征。接下来，我们重点介绍 circRNAs 在 1 型糖尿病、2 型糖尿病、妊娠期糖尿病和糖尿病相关并发症中的具体作用。
