Department of Microbiology and Immunology, School of Medicine, University of North Carolina Chapel Hill, NC, USA; Marsico Lung Institute, School of Medicine, University of North Carolina Chapel Hill, NC, USA.
Marsico Lung Institute, School of Medicine, University of North Carolina Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina Chapel Hill, NC, USA.
Int J Biochem Cell Biol. 2024 May;170:106568. doi: 10.1016/j.biocel.2024.106568. Epub 2024 Mar 20.
Regulatory T cells, characterized by their expression of the transcription factor Forkhead box P3, are indispensable in maintaining immune homeostasis. The respiratory system is constantly exposed to many environmental challenges, making it susceptible to various insults and infections. Regulatory T cells play essential roles in maintaining homeostasis in the lung and promoting repair after injury. Regulatory T cell function dysregulation can lead to inflammation, tissue damage, or aberrant repair. Research on regulatory T cell mechanisms in the lung has unveiled their influence on lung inflammation and repair mechanisms. In this review, our goal is to highlight the advances in regulatory T cell biology with respect to lung injury and resolution. We further provide a perspective that a deeper understanding of regulatory T cell interactions in the lung microenvironment in health and disease states offers opportunities for therapeutic interventions as treatments to promote lung health.
调节性 T 细胞（Regulatory T cells），其特征在于表达转录因子叉头框 P3，对于维持免疫稳态是不可或缺的。呼吸系统不断暴露于许多环境挑战中，使其容易受到各种损伤和感染。调节性 T 细胞在维持肺内稳态和促进损伤后修复方面发挥着重要作用。调节性 T 细胞功能失调可导致炎症、组织损伤或异常修复。对肺中调节性 T 细胞机制的研究揭示了它们对肺炎症和修复机制的影响。在这篇综述中，我们的目标是强调调节性 T 细胞生物学在肺损伤和解决方面的进展。我们进一步提供了一种观点，即深入了解健康和疾病状态下肺微环境中调节性 T 细胞的相互作用为促进肺健康的治疗干预提供了机会。
