Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.
Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland; University Research Priority Program (URPP), Adaptive Brain Circuits in Development and Learning, University of Zurich, Zurich, Switzerland.
Cell Rep. 2024 Apr 23;43(4):113968. doi: 10.1016/j.celrep.2024.113968. Epub 2024 Mar 22.
The habenula is an evolutionarily highly conserved diencephalic brain region divided into two major parts, medial and lateral. Over the past two decades, studies of the lateral habenula (LHb), in particular, have identified key functions in value-guided behavior in health and disease. In this review, we focus on recent insights into LHb connectivity and its functional relevance for different types of aversive and appetitive value-guided behavior. First, we give an overview of the anatomical organization of the LHb and its main cellular composition. Next, we elaborate on how distinct LHb neuronal subpopulations encode aversive and appetitive stimuli and on their involvement in more complex decision-making processes. Finally, we scrutinize the afferent and efferent connections of the LHb and discuss their functional implications for LHb-dependent behavior. A deepened understanding of distinct LHb circuit components will substantially contribute to our knowledge of value-guided behavior.
缰核是一个在进化上高度保守的间脑区域，分为两个主要部分，内侧和外侧。在过去的二十年中，对外侧缰核（LHb）的研究特别确定了其在健康和疾病中的价值引导行为中的关键功能。在这篇综述中，我们重点介绍了 LHb 连接的最新见解及其对不同类型的厌恶和渴望价值引导行为的功能相关性。首先，我们概述了 LHb 的解剖组织及其主要细胞组成。接下来，我们详细阐述了不同的 LHb 神经元亚群如何编码厌恶和渴望刺激，以及它们如何参与更复杂的决策过程。最后，我们仔细研究了 LHb 的传入和传出连接，并讨论了它们对 LHb 依赖行为的功能意义。对不同的 LHb 回路成分的深入了解将极大地促进我们对价值引导行为的认识。
