Human Biomonitoring Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1 A-B Rue Thomas Edison, 1445, Strassen, Luxembourg.
L'Oréal Research and Innovation, 1 Avenue Eugène Schueller BP22, 93601, Aulnay Sous Bois, France.
Environ Pollut. 2024 May 1;348:123839. doi: 10.1016/j.envpol.2024.123839. Epub 2024 Mar 22.
Bisphenols and pesticides have been shown to alter circulating glucocorticoids levels in animals, but there is limited human data. Moreover, measurements from biological fluids may not be able to reflect long-term status of non-persistent pollutants and glucocorticoids due to the high variability in their levels. Using hair analysis, we examined the associations between glucocorticoid hormones and environmental exposure to multi-class organic pollutants among a healthy female population aged 25-45 years old. Concentrations of four glucocorticoids, four polychlorinated biphenyl congeners (PCBs), seven polybrominated diphenyl ether congeners (PBDEs), two bisphenols and 140 pesticides and their metabolites were measured in hair samples collected from 196 Chinese women living in urban areas. Due to the low detection frequency of some pollutants, associations were explored only on 54 pollutants, i.e. PCB 180, bisphenol A, bisphenol S and 51 pesticides and their metabolites. Using stability-based Lasso regression, there were associations of cortisol, tetrahydrocortisol, cortisone, and tetrahydrocortisone with 14, 10, 13 and 17 biomarkers of exposure to pollutants, respectively, with bisphenol S, p,p'-dichlorodiphenyldichloroethylene, diethyl phosphate, 3,5,6-trichloro-2-pyridinol, thiamethoxam, imidacloprid, fipronil, tebuconazole, trifluralin, pyraclostrobin and 1-(3,4-dichlorophenyl)-3-methylurea being associated with at least three of the four hormones. There were also associations between cortisone/cortisol molar ratio and pollutants, namely dimethyl phosphate, 3-methyl-4-nitrophenol, carbofuran, λ-cyhalothrin, permethrin, fipronil, flusilazole, prometryn and fenuron. Some of these relationships were confirmed by single-pollutant linear regression analyses. Overall, our results suggest that background level of exposure to bisphenols and currently used pesticides may interfere with the glucocorticoid homeostasis in healthy women.
双酚类化合物和农药已被证明会改变动物体内循环的糖皮质激素水平，但人类的数据有限。此外，由于生物体液中这些物质的水平变化很大，因此其测量结果可能无法反映非持久性污染物和糖皮质激素的长期状态。本研究使用毛发分析方法，在 25-45 岁的健康女性人群中，研究了糖皮质激素激素与多类有机污染物环境暴露之间的关系。在采集的 196 名居住在城市地区的中国女性的头发样本中，测量了四种糖皮质激素、四种多氯联苯同系物（PCBs）、七种多溴二苯醚同系物（PBDEs）、两种双酚类化合物和 140 种农药及其代谢物的浓度。由于某些污染物的检测频率较低，因此仅对 54 种污染物（即 PCB180、双酚 A、双酚 S 和 51 种农药及其代谢物）进行了相关性探讨。使用基于稳定性的 Lasso 回归，发现皮质醇、四氢皮质醇、可的松和四氢可的松分别与 14、10、13 和 17 种污染物暴露生物标志物相关，其中双酚 S、p,p'-二氯二苯二氯乙烯、二乙基磷酸、3,5,6-三氯-2-吡啶醇、噻虫嗪、吡虫啉、氟虫腈、戊唑醇、三氟草嗪、吡唑醚菌酯和 1-(3,4-二氯苯基)-3-甲基脲与至少三种激素相关。可的松/皮质醇摩尔比与污染物（即二甲基磷酸、3-甲基-4-硝基苯酚、克百威、λ-氯氟氰菊酯、氯菊酯、氟虫腈、氟唑菌酰胺、扑草净和灭草隆）之间也存在关联。一些关系通过单污染物线性回归分析得到了证实。总的来说，我们的研究结果表明，双酚类化合物和目前使用的农药的背景暴露水平可能会干扰健康女性的糖皮质激素内稳态。
