Siennicki-Lantz Arkadiusz, André-Petersson Lena, Elmståhl Sölve
Section of Geriatric Medicine, Department of Clinical Sciences in Malmö, Lund University, Malmö, SWEDEN.
Section of Neurology, Department of Clinical Sciences in Malmö, Lund University, Malmö, SWEDEN.
Cereb Circ Cogn Behav. 2024 Mar 14;6:100220. doi: 10.1016/j.cccb.2024.100220. eCollection 2024.
Cognitive and perfusion changes have been previously observed in older men with Mini Mental State Examination scores>24 points. We aimed to investigate time change in cognitive domains in a cohort of non-demented men between age 68 and 82, and how they are expressed in regional defects estimated by Cerebral Blood Flow (rCBF).
103 men at age 81 with MMSE scores >24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with the same cognitive test battery at age 68 and age 81: Synonyms (SRB-1), Block design (SRB-3), Paired Associates, Digit Symbol Substitution and Benton Visual Retention test. rCBF was estimated using -HMPAO SPECT at age 82.
Between ages 68 and 82 we observed a relative decline (Δ%) of cognitive test scores: SRB-3 and Benton tests, -33.7 % (SD 16,8) and -25.8 % (SD 23.9) respectively, followed by Digit Symbol test: -22,6 % (SD 15,6). The cluster of men (46 %) could be detected, grouped on the largest test score decline and highest overall test predictors' importance in decreasing order: Δ% SRB-3, Δ% Paired Associates, Δ% Digit Symbol, Δ% Benton VR and Δ% SRB-1. Compared to the cluster with stable cognitive functions, it expressed lower rCBF in frontal and parietal lobes, and in subcortical areas.
Nearly half of the studied, community-dwelling cohort of non-demented, octogenarian men with MMSE > 24, had a combination of decreasing visuospatial ability and episodic memory during preceding years, expressed by widespread rCBF changes in fronto-subcortical areas.
先前已观察到简易精神状态检查表得分>24分的老年男性存在认知和灌注变化。我们旨在研究68至82岁非痴呆男性队列中认知领域随时间的变化，以及这些变化如何通过脑血流量（rCBF）估计的区域缺陷表现出来。
对103名81岁、MMSE得分>24（平均28.4±1.7）、无痴呆或中风的男性，在68岁和81岁时使用相同的认知测试组合进行检查：同义词（SRB-1）、积木设计（SRB-3）、配对联想学习、数字符号替换和本顿视觉保持测试。在82岁时使用-HMPAO单光子发射计算机断层扫描估计rCBF。
在68岁至82岁之间，我们观察到认知测试分数的相对下降（Δ%）：SRB-3和本顿测试分别下降-33.7%（标准差16.8）和-25.8%（标准差23.9），其次是数字符号测试：-22.6%（标准差15.6）。可以检测到一组男性（46%），按最大测试分数下降和总体测试预测指标的最高重要性降序分组：Δ%SRB-3、Δ%配对联想学习、Δ%数字符号、Δ%本顿视觉保持和Δ%SRB-1。与认知功能稳定的组相比，该组在额叶、顶叶和皮质下区域的rCBF较低。
在研究的近一半社区居住的非痴呆、MMSE>24的八旬男性队列中，在前几年中存在视觉空间能力和情景记忆下降的组合，表现为额-皮质下区域广泛的rCBF变化。
