Medina-Berríos Nataniel, Pantoja-Romero Wenndy, Lavín Flores Alexis, Díaz Vélez Sebastián C, Martínez Guadalupe Anna C, Torres Mulero Mariana T, Kisslinger Kim, Martínez-Ferrer Magaly, Morell Gerardo, Weiner Brad R
Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, San Juan 00925-253, Puerto Rico.
Molecular Sciences Research Center, University of Puerto Rico, San Juan 00925-253, Puerto Rico.
ACS Omega. 2024 Mar 6;9(11):12575-12584. doi: 10.1021/acsomega.3c06252. eCollection 2024 Mar 19.
Carbon-based quantum dots (CBQDs), sulfur-doped carbon-based quantum dots (S-CBQDs), and nitrogen-doped carbon-based quantum dots (N-CBQDs) have strong potential for drug delivery platforms. They were conjugated with andrographolide, a well-known hydrophobic drug, to study the concomitant changes in hydrophilicity. The interactions between these nanomaterials and the drug were studied by characterizing the optical and structural properties of the nanoparticles before and after coupling with the drug. It was found that the interaction of the drug with these nanomaterials produced noticeable changes in their optical and structural properties. Moreover, the partition coefficient for the nanocomposites was determined by NMR. The results indicate that conjugating the drug with the nanoparticles significantly enhanced its affinity for the aqueous phase, from 2.632 to 0.1117, thereby opening the possibility of using this approach for developing an effective drug delivery platform for this hydrophobic drug.
碳基量子点（CBQDs）、硫掺杂碳基量子点（S-CBQDs）和氮掺杂碳基量子点（N-CBQDs）在药物递送平台方面具有巨大潜力。它们与穿心莲内酯（一种著名的疏水性药物）共轭，以研究亲水性的相应变化。通过表征纳米颗粒与药物偶联前后的光学和结构性质，研究了这些纳米材料与药物之间的相互作用。结果发现，药物与这些纳米材料的相互作用使其光学和结构性质发生了显著变化。此外，通过核磁共振测定了纳米复合材料的分配系数。结果表明，药物与纳米颗粒共轭后，其对水相的亲和力显著增强，从2.632提高到0.1117，从而为开发这种疏水性药物的有效药物递送平台开辟了可能性。
