石墨烯量子点的合成及其在药物传递中的应用。
Synthesis of graphene quantum dots and their applications in drug delivery.
机构信息
School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, 453003, P. R. China.
Electronics Materials and Systems Laboratory, Department of Microtechnology and Nanoscience, Chalmers University of Technology, 412 96, Gothenburg, Sweden.
出版信息
J Nanobiotechnology. 2020 Oct 2;18(1):142. doi: 10.1186/s12951-020-00698-z.
This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.
这篇综述聚焦于石墨烯量子点（GQDs）的合成及其在药物传递方面的应用的最新进展。为了简要了解 GQDs 的制备，首先介绍了 GQDs 合成方法的最新进展。随后，综述了基于 GQDs 的药物传递系统的各种药物传递/释放模式，如 EPR-pH 传递/释放模式、配体-pH 传递/释放模式、EPR-光热传递/释放模式和核/壳-光热/磁热传递/释放模式。最后，讨论了 GQDs 在药物传递中的当前挑战和未来应用前景。
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