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用于治疗结直肠癌的pH响应性Fe-MOF@GO复合药物递送系统的合成、表征及疗效评估

Synthesis, characterization, and efficacy evaluation of a PH-responsive Fe-MOF@GO composite drug delivery system for the treating colorectal cancer.

作者信息

Shen Jia-Jie, Xue Shi-Jiao, Mei Zhang-Hao, Li Ting-Ting, Li Hui-Fen, Zhuang Xue-Fei, Pan Lin-Mei

机构信息

Plant medicine Deep Processing Engineering Center, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Qidong Hospital of Traditional Chinese Medicine, Nantong, 226200, China.

出版信息

Heliyon. 2024 Mar 15;10(6):e28066. doi: 10.1016/j.heliyon.2024.e28066. eCollection 2024 Mar 30.

DOI:10.1016/j.heliyon.2024.e28066
PMID:38524612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10957435/
Abstract

Luteolin is a potent anti-colorectal cancer chemical. However, its effectiveness is hindered by its poor solubility in water and fat, and it is easy to degrade by gastrointestinal enzymes. In this study, a nano-composite carrier, NH-MIL-101(Fe)@GO (MG), based on aminated MIL-101(Fe) and graphene oxide (GO) was developed and evaluated. This carrier co-delivered luteolin and matrine, while marine was used to balance the pH for the nano-preparation. The loading capacities for luteolin and matrine were approximately 9.8% and 14.1%, respectively. Luteolin's release at pH = 5 was significantly higher than at pH = 7.4, indicating it had an acidic pH response release characteristic. Compared to MOF and GO alone, MG and NH2-MIL-101(Fe)@GO@Drugs (MGD) enhanced anti-cancer activity by inhibiting tumor cell migration, increasing ROS generation, and upregulating the expression of Caspase-3 and Caspase-9. In conclusion, this study contributes new ideas and methods to the treatment strategy of multi-component anti-colorectal cancer therapy. It also advances drug delivery systems and supports the development of more effective and targeted treatment approaches for colorectal cancer.

摘要

木犀草素是一种有效的抗结直肠癌化学物质。然而，其水溶性和脂溶性较差，且易被胃肠道酶降解，这阻碍了其有效性。在本研究中，基于胺化的MIL-101(Fe)和氧化石墨烯(GO)开发并评估了一种纳米复合载体NH-MIL-101(Fe)@GO (MG)。该载体共递送木犀草素和苦参碱，同时用海泡石平衡纳米制剂的pH值。木犀草素和苦参碱的负载量分别约为9.8%和14.1%。木犀草素在pH = 5时的释放量显著高于pH = 7.4时，表明其具有酸性pH响应释放特性。与单独的MOF和GO相比，MG和NH2-MIL-101(Fe)@GO@药物(MGD)通过抑制肿瘤细胞迁移、增加ROS生成以及上调Caspase-3和Caspase-9的表达来增强抗癌活性。总之，本研究为多组分抗结直肠癌治疗策略贡献了新的思路和方法。它还推动了药物递送系统的发展，并支持开发更有效、更有针对性的结直肠癌治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/d6733e95896f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/fe8c36212f6e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/62b03bd451ad/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/178b4f49178a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/6a9bd22b94f4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/c33660f69206/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/7694bfe2726a/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/d6733e95896f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/fe8c36212f6e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/62b03bd451ad/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/178b4f49178a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/6a9bd22b94f4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/c33660f69206/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/7694bfe2726a/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f78/10957435/d6733e95896f/gr7.jpg

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