纳米药物递送系统调节肿瘤血管以增强渗透和滞留效应。

Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect.

作者信息

Huang Dong, Sun Lingna, Huang Leaf, Chen Yanzuo

机构信息

Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China.

Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

出版信息

J Pers Med. 2021 Feb 14;11(2):124. doi: 10.3390/jpm11020124.

DOI:10.3390/jpm11020124

PMID:33672813

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7917988/

Abstract

The use of nanomedicine for antitumor therapy has been extensively investigated for a long time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently regarded as an effective way to bring drugs to tumors, especially macromolecular drugs and drug-loaded pharmaceutical nanocarriers. However, a disordered vessel network, and occluded or embolized tumor blood vessels seriously limit the EPR effect. To augment the EPR effect and improve curative effects, in this review, we focused on the perspective of tumor blood vessels, and analyzed the relationship among abnormal angiogenesis, abnormal vascular structure, irregular blood flow, extensive permeability of tumor vessels, and the EPR effect. In this commentary, nanoparticles including liposomes, micelles, and polymers extravasate through the tumor vasculature, which are based on modulating tumor vessels, to increase the EPR effect, thereby increasing their therapeutic effect.

摘要

长期以来，纳米医学在抗肿瘤治疗中的应用已得到广泛研究。增强渗透与滞留（EPR）效应介导的药物递送目前被认为是将药物输送到肿瘤的有效途径，尤其是大分子药物和载药纳米载体。然而，紊乱的血管网络以及闭塞或栓塞的肿瘤血管严重限制了EPR效应。为增强EPR效应并提高疗效，在本综述中，我们从肿瘤血管的角度出发，分析了异常血管生成、异常血管结构、不规则血流、肿瘤血管广泛通透性与EPR效应之间的关系。在本述评中，包括脂质体、胶束和聚合物在内的纳米颗粒通过调节肿瘤血管，经肿瘤脉管系统渗出，以增强EPR效应，从而提高其治疗效果。