Department of Radiotherapy, Second Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, People's Republic of China.
Int J Nanomedicine. 2024 Mar 18;19:2823-2849. doi: 10.2147/IJN.S451151. eCollection 2024.
Currently, pancreatic cancer (PC) is one of the most lethal malignant tumors. PC is typically diagnosed at a late stage, exhibits a poor response to conventional treatment, and has a bleak prognosis. Unfortunately, PC's survival rate has not significantly improved since the 1960s. Cancer-associated fibroblasts (CAFs) are a key component of the pancreatic tumor microenvironment (TME). They play a vital role in maintaining the extracellular matrix and facilitating the intricate communication between cancer cells and infiltrated immune cells. Exploring therapeutic approaches targeting CAFs may reverse the current landscape of PC therapy. In recent years, nano-drug delivery systems have evolved rapidly and have been able to accurately target and precisely release drugs with little or no toxicity to the whole body. In this review, we will comprehensively discuss the origin, heterogeneity, potential targets, and recent advances in the nano-drug delivery system of CAFs in PC. We will also propose a novel integrated treatment regimen that utilizes a nano-drug delivery system to target CAFs in PC, combined with radiotherapy and immunotherapy. Additionally, we will address the challenges that this regimen currently faces.
目前，胰腺癌（PC）是最致命的恶性肿瘤之一。PC 通常在晚期诊断，对常规治疗反应不佳，预后不良。不幸的是，自 20 世纪 60 年代以来，PC 的生存率并没有显著提高。癌症相关成纤维细胞（CAFs）是胰腺肿瘤微环境（TME）的关键组成部分。它们在维持细胞外基质和促进癌细胞与浸润免疫细胞之间的复杂通信方面发挥着至关重要的作用。探索针对 CAFs 的治疗方法可能会改变目前 PC 治疗的格局。近年来，纳米药物递送系统发展迅速，能够准确靶向并精确释放药物，对全身几乎没有或没有毒性。在这篇综述中，我们将全面讨论 PC 中 CAFs 的起源、异质性、潜在靶点和纳米药物递送系统的最新进展。我们还将提出一种利用纳米药物递送系统靶向 PC 中 CAFs 的新的综合治疗方案，结合放疗和免疫疗法。此外，我们将讨论该方案目前面临的挑战。
