Ageru Temesgen Anjulo, Seid Habtamu, Abiso Temesgen Lera, Kumalo Abera, Sidamo Temesgen, Balcha Tamrat
Department of Medical Laboratory Services, Wolaita Sodo University Comprehensive Specialized Hospital, Wolaita, P.O. Box 138, Ethiopia.
School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita, P.O. Box 138, Ethiopia.
Biomed Res Int. 2022 Jun 2;2022:7272024. doi: 10.1155/2022/7272024. eCollection 2022.
Antibiotic resistance is a serious threat to the human population everywhere. However, less attention is given to its concern in sub-Saharan Africa including Ethiopia. There is an information gap concerning antibiotic resistance and its pattern in Wolaita Sodo University Teaching Referral Hospital. This study is aimed at investigating the prevalence of antimicrobial resistance in the study area.
Five-year retrospective data of cultures and records of 581 patients were utilized to analyze the pattern of antibiotic resistance. The statistical software including SPSS version 25 and Microsoft excel 2013 were used. Laboratory records with incompletely registered age, sex, culture isolation, or drug susceptibility test data were excluded.
Out of the total of 581 samples extracted from the microbiology laboratory, 237 (40.8%) samples were culture positive for bacteria. From positive culture growth, 165 (69.6%) were gram-positive bacteria whereas 72 (30.4%) were gram negative. was the most prevalent isolate among gram-positive isolates as was for gram-negative isolates. Overall antibiotic resistance of gram-positive isolates was 57.2% whereas that of gram-negative bacteria was 58.8%.
and were found to be the most prevalent pathogenic isolates among gram-positive and gram-negative bacteria, respectively. Most of the isolated pathogens showed high resistance towards the commonly prescribed antibiotic agents. The overall antibiotic resistance in this study was 57.7%, and the overall MDR prevalence was 72.2%.
抗生素耐药性对世界各地的人类构成严重威胁。然而，在包括埃塞俄比亚在内的撒哈拉以南非洲地区，人们对其关注较少。在沃莱塔索多大学教学转诊医院，关于抗生素耐药性及其模式存在信息空白。本研究旨在调查研究区域内抗菌药物耐药性的流行情况。
利用581例患者的五年培养回顾性数据和记录来分析抗生素耐药模式。使用了包括SPSS 25版和Microsoft Excel 2013在内的统计软件。排除年龄、性别、培养分离或药敏试验数据登记不完整的实验室记录。
从微生物实验室提取的581份样本中，237份（40.8%）样本细菌培养呈阳性。在阳性培养物中，165份（69.6%）为革兰氏阳性菌，72份（30.4%）为革兰氏阴性菌。 是革兰氏阳性菌中最常见的分离株， 是革兰氏阴性菌中最常见的分离株。革兰氏阳性菌分离株的总体抗生素耐药率为57.2%，而革兰氏阴性菌的总体抗生素耐药率为58.8%。
和 分别被发现是革兰氏阳性菌和革兰氏阴性菌中最常见的致病分离株。大多数分离出的病原体对常用的抗生素药物表现出高度耐药性。本研究中的总体抗生素耐药率为57.7%，总体多重耐药率为72.2%。
