Li Yanping, Kumar Suresh, Zhang Lihu
Pharmacy Department, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu, People's Republic of China.
Post Graduate Centre, Management and Science University, Shah Alam, Malaysia.
Infect Drug Resist. 2024 Mar 19;17:1107-1119. doi: 10.2147/IDR.S453025. eCollection 2024.
Infections with drug-resistant bacteria have become one of the greatest public health challenges, and is among the top six drug-resistant bacteria. often causes nosocomial infections, leading to illnesses such as pneumonia, liver abscesses, soft tissue infections, urinary tract infections, bacteremia, and in some cases death. As the pathogen continues to evolve and its multidrug resistance increases, poses a direct threat to humans. Drug resistance in may occur due to the formation of biofilms, efflux pumps, and the production of β-lactamases. In many cases, resistance is further enhanced by enzymatic modification and loss of porins. Drug resistance to has led to a decline in the effectiveness of conventional therapies against this pathogen. Therefore, there is an urgent need to accelerate the development of new antibiotics and explore new therapeutic approaches such as antimicrobial peptides, phages, traditional Chinese medicine, immunotherapy, Antimicrobial nanoparticle technology, antisense oligonucleotides and gene editing technologies. In this review, we discuss the mechanisms of drug resistance in and compare several new potential therapeutic strategies to overcome drug resistance in the treatment of infections.
耐药菌感染已成为最大的公共卫生挑战之一，且是六大耐药菌之一。它常引发医院感染，导致诸如肺炎、肝脓肿、软组织感染、尿路感染、菌血症等疾病，在某些情况下还会导致死亡。随着病原体不断进化且其多重耐药性增强，它对人类构成了直接威胁。该菌的耐药性可能因生物膜形成、外排泵以及β-内酰胺酶的产生而出现。在许多情况下，酶修饰和孔蛋白丢失会进一步增强耐药性。对该菌的耐药性已导致针对这种病原体的传统疗法疗效下降。因此，迫切需要加速新型抗生素的研发，并探索新的治疗方法，如抗菌肽、噬菌体、中药、免疫疗法、抗菌纳米颗粒技术、反义寡核苷酸和基因编辑技术。在本综述中，我们讨论了该菌的耐药机制，并比较了几种新的潜在治疗策略，以克服在治疗该菌感染时的耐药性。
