Saifi Sana, Ashraf Anam, Hasan Gulam Mustafa, Shamsi Anas, Hassan Md Imtaiyaz
Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Fitoterapia. 2024 Mar;173:105811. doi: 10.1016/j.fitote.2023.105811. Epub 2023 Dec 31.
Klebsiella pneumoniae is a type of Gram-negative bacteria that causes a variety of infections, including pneumonia, bloodstream infections, wound infections, and meningitis. The treatment of K. pneumoniae infection depends on the type of infection and the severity of the symptoms. Antibiotics are generally used to treat K. pneumoniae infections. However, some strains of K. pneumoniae have become resistant to antibiotics. This comprehensive review examines the potential of natural compounds as effective strategies against K. pneumonia infections. The alarming rise in antibiotic resistance underscores the urgent need for alternative therapies. This article represents current research on the effects of diverse natural compounds, highlighting their anti-microbial and antibiofilm properties against K. pneumonia. Notably, compounds such as andrographolide, artemisinin, baicalin, berberine, curcumin, epigallocatechin gallate, eugenol, mangiferin, piperine, quercetin, resveratrol, and thymol have been extensively investigated. These compounds exhibit multifaceted mechanisms, including disruption of bacterial biofilms, interference with virulence factors, and augmentation of antibiotic effectiveness. Mechanistic insights into their actions include membrane perturbation, oxidative stress induction, and altered gene expression. While promising, challenges such as limited bioavailability and varied efficacy across bacterial strains are addressed. This review further discusses the potential of natural compounds as better alternatives in combating K. pneumonia infection and emphasizes the need for continued research to harness their full therapeutic potential. As antibiotic resistance persists, these natural compounds offer a promising avenue in the fight against K. pneumonia and other multidrug-resistant pathogens.
肺炎克雷伯菌是一种革兰氏阴性菌，可引起多种感染，包括肺炎、血流感染、伤口感染和脑膜炎。肺炎克雷伯菌感染的治疗取决于感染类型和症状严重程度。抗生素通常用于治疗肺炎克雷伯菌感染。然而，一些肺炎克雷伯菌菌株已对抗生素产生耐药性。这篇综述探讨了天然化合物作为对抗肺炎克雷伯菌感染有效策略的潜力。抗生素耐药性的惊人上升凸显了对替代疗法的迫切需求。本文介绍了当前关于多种天然化合物作用的研究，重点阐述了它们对肺炎克雷伯菌的抗菌和抗生物膜特性。值得注意的是，穿心莲内酯、青蒿素、黄芩苷、小檗碱、姜黄素、表没食子儿茶素没食子酸酯、丁香酚、芒果苷、胡椒碱、槲皮素、白藜芦醇和百里香酚等化合物已得到广泛研究。这些化合物具有多方面的作用机制，包括破坏细菌生物膜、干扰毒力因子以及增强抗生素疗效。对其作用机制的深入了解包括膜扰动、氧化应激诱导和基因表达改变。虽然前景广阔，但也存在生物利用度有限和不同菌株疗效各异等挑战。本综述进一步讨论了天然化合物作为对抗肺炎克雷伯菌感染更好替代物的潜力，并强调需要持续研究以充分发挥其治疗潜力。随着抗生素耐药性持续存在，这些天然化合物为对抗肺炎克雷伯菌和其他多重耐药病原体提供了一条有前景的途径。
