有缺陷的 MIREC 氟化物与智商出版物：破坏社区饮水氟化的失败尝试。

Flawed MIREC fluoride and intelligence quotient publications: A failed attempt to undermine community water fluoridation.

机构信息

Department of Community Health Sciences and Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

School of Psychology, Queen's University, Belfast, UK.

出版信息

Community Dent Oral Epidemiol. 2024 Aug;52(4):365-374. doi: 10.1111/cdoe.12954. Epub 2024 Mar 25.

DOI:10.1111/cdoe.12954

PMID:38525812

Abstract

OBJECTIVE

To assess the evidence presented in a set of articles that use the Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) study database to claim that community water fluoridation (CWF) is associated with harm to foetal and infant cognitive development.

METHODS

Critical appraisal of measurements and processes in the MIREC database, and articles derived therefrom. MIREC's cohort is approximately 2000 pregnant women recruited in 10 centres across Canada, 2008-2011, leading to measuring 512 children aged 3-6 years in six cities. Fluoride exposure was measured by city fluoridation status, self-reports and maternal spot urine samples. Intelligence Quotient (IQ) was measured using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) by different assessors in each city.

RESULTS

MIREC's fluoride and IQ measurements are invalid and therefore cannot support the claim that CWF is associated with IQ decline in children.

CONCLUSIONS

The MIREC fluoride-IQ articles' results should be considered unacceptable for legal and policy purposes; other water fluoridation studies and systematic reviews show no effect of fluoridation on cognition.

摘要

目的

评估一组使用加拿大母婴环境化学研究（MIREC）研究数据库的文章所提出的证据，这些文章声称社区饮水氟化（CWF）与胎儿和婴儿认知发育受损有关。

方法

对 MIREC 数据库中的测量和处理方法以及由此衍生的文章进行批判性评估。MIREC 的队列由 2008 年至 2011 年在加拿大 10 个中心招募的大约 2000 名孕妇组成，最终在六个城市测量了 512 名 3-6 岁的儿童。氟化物暴露通过城市氟化状况、自我报告和母亲的点尿样进行测量。智商（IQ）使用每个城市不同评估员的韦氏学前和小学智力量表（WPPSI-III）进行测量。